In vivo imaging of adult neurogenesis
In vivo imaging of adult neurogenesis
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DOI：
10.1111/j.1460-9568.2011.07601.x
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发表时间：
2011-03-01
影响因子：
3.4
通讯作者：
Aigner, Ludwig
中科院分区：
文献类型：
--
作者：
Couillard-Despres, Sebastien;Aigner, Ludwig
随着我们对成人神经发生的理解的增加，神经系统疾病和神经元损失有一天可能通过基于神经干细胞的再生疗法来解决的希望也随之增加。然而，评估任何基于神经发生的干预措施的有效性和安全性需要一种监测体内神经发生的方法，到目前为止，还没有这种成像技术可用于人体研究。然而，使用目前临床医生可用的成像技术，即磁共振成像，正电子发射断层扫描和光学成像，在过去十年中在这一方向上取得了重大进展。这篇综述描述了目前每种成像技术的最新发展水平，并表明理论上可以使用当前的成像设备来实现神经发生的检测。事实上，已经在小鼠中使用转基因模型系统实现了神经发生的体内成像。然而，人类神经发生的成像仍然需要开发可靠地靶向体内神经干细胞和神经元前体的方法。
As our understanding of adult neurogenesis increases, hopes rise that neurological disorders and neuronal losses might be addressed one day by neural stem cell-based regenerative therapies. However, evaluating the efficacy and safety of any neurogenesis-based intervention requires a means to monitor neurogenesis in vivo and, so far, no such imaging techniques are available for human studies. Nevertheless, using imaging techniques presently available to clinicians, i.e. magnetic resonance imaging, positron emission tomography and optical imaging, significant progress has been made in this direction over the last decade. This review describes the current state-of-the-art for each imaging technique, and shows that detection of neurogenesis could theoretically be achieved using current imaging devices. Indeed, in vivo imaging of neurogenesis has already been achieved in mice using transgenic model systems. However, the imaging of human neurogenesis still requires the development of methods to reliably target the neural stem cells and the neuronal precursors in vivo.