Targets of cyclin-dependent protein kinases

Targets of cyclin-dependent protein kinases
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DOI:
10.1016/0955-0674(93)90101-u
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发表时间:
1993-04-01
影响因子:
7.5
通讯作者:
Nigg, Erich A.
Nigg, Erich A.
中科院分区:
生物学2区
文献类型:
--
作者:
Nigg, Erich A.

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我们目前对真核细胞周期的理解将一个关键的调节作用归因于细胞周期蛋白依赖的蛋白激酶。因此,重要的是要确定这些激酶的生理底物,并了解这些蛋白的磷酸化如何促进细胞周期进展。
Our current understanding of the eukaryotic cell cycle attributes a key regulatory role to cyclin-dependent protein kinases. It is important, therefore, to identify the physiological substrates of these kinases, and to understand how the phosphorylation of such proteins promotes cell cycle progression.