Arsenic-related Bowen's disease, Palmar keratosis, and skin cancer
Arsenic-related Bowen's disease, Palmar keratosis, and skin cancer
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DOI：
10.2307/3434463
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发表时间：
1999-08-01
影响因子：
10.4
通讯作者：
Öztürk, S
中科院分区：
文献类型：
--
作者：
Çöl, M;Çöl, C;Öztürk, S
慢性砷中毒仍然可以在环境和工业环境中发现。慢性砷中毒的症状包括皮肤的一般色素沉着或局灶性“雨滴”色素沉着以及手掌和脚底出现角化过度。除了与砷有关的皮肤病，包括角化病、鲍文氏病、基底细胞癌和鳞状细胞癌外，一些内部恶性肿瘤的风险也会增加。在世界上饮用水砷含量高的地区，与砷有关的疾病很常见。在本文中，我们描述一位35岁的男性患者，他患有砷相关的角化病、左手手掌区的鳞状细胞癌和左大腿的鲍文氏病。病人在一家煤矿工作了15年，因此他暴露于饮用水中的砷，工作场所空气中的砷，并有直接接触。该患者接受了11个月的砷相关角化病治疗，直到腋窝淋巴结转移发生;病变切除，诊断为恶性。鲍文病是在病人接受癌症治疗时发现的。未发现其他恶性肿瘤，患者仍在接受定期随访。
Chronic arsenical intoxication can still be found in environmental and industrial settings. Symptoms of chronic arsenic intoxication include general pigmentation or focal "raindrop" pigmentation of the skin and the appearance of hyperkeratosis of the palms of the hands and soles of the feet. In addition to arsenic-related skin diseases including keratosis, Bowen's disease, basal-cell-carcinoma, and squamous-cell carcinoma, there is also an increased risk of some internal malignancies. Arsenic-related diseases are common in areas of the world where the drinking water has a high arsenic content. In this paper, we describe a 35-year-old male patient who had arsenic-related keratosis, squamous-cell carcinoma in the palmar area of his left hand, and Bowen's disease on his left thigh. The patient worked in a borax mine for 15 years, so he was exposed to arsenic in drinking water, airborne arsenic in his workplace, and had direct contact. The patient was treated for 11 months for arsenic-related keratosis until an axillary lymph node metastasis occurred; the lesion was excised and diagnosed to be malignant. Bowen's disease was detected when the patient was being treated for cancer. No other malignancy was found. The patient is still receiving regular follow-up care.