Offspring sex ratios at birth as markers of paternal endocrine disruption
Offspring sex ratios at birth as markers of paternal endocrine disruption
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DOI：
10.1016/j.envres.2005.03.001
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发表时间：
2006-01-01
影响因子：
8.3
通讯作者：
James, WH
中科院分区：
文献类型：
--
作者：
James, WH
有充分的证据表明，受孕时的父本（和母本）激素水平与后代出生时的性别比例（交配比例）相关。这种关联的潜在机制（合子前或合子后）在这里并不具有主要相关性。当人们接触内分泌干扰剂时，这些物质可能对男性和女性产生不同的荷尔蒙影响。因此，如果要通过后代性别比来揭示内分泌紊乱，则有必要按四种可能的亲本交配类别对后代的性别进行分类，即：暴露/未暴露的母亲/父亲。一般来说，性别比的大幅改变可能会揭示内分泌紊乱，但20世纪（及之前）全国活产性别比的微小（诚然重要）长期变化现在还不容易解释。 (c) 2005 Elsevier Inc. 保留所有权利。
There is good evidence that paternal (and maternal) hormone levels at the time of conception are associated with offspring sex ratios (proportions mate) at birth. The mechanisms underlying this association (pre- or postzygotic) are not of primary relevance here. When people are exposed to endocrine-disrupting agents, these agents may have different hormonal effects oil men and women. So, if endocrine disruption is to be revealed by offspring sex ratios, it is necessary to categorize the sexes of subsequent offspring by the four possible parental mating classes, viz. exposed/unexposed mothers/fathers. In general, substantially altered sex ratios may reveal endocrine disruption, but the tiny (admittedly significant) secular meanderings of national live birth sex ratios across the 20th Century (and before) are not now readily interpretable. (c) 2005 Elsevier Inc. All rights reserved.