Effect of parental history of diabetes on markers of inflammation, insulin resistance and atherosclerosis in first degree relatives of patients with type 2 diabetes mellitus
Effect of parental history of diabetes on markers of inflammation, insulin resistance and atherosclerosis in first degree relatives of patients with type 2 diabetes mellitus
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DOI：
10.1016/j.dsx.2017.12.004
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发表时间：
2018-05-01
影响因子：
10
通讯作者：
Baliarsinha, Anoj Kumar
中科院分区：
文献类型：
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作者：
Dash, Deepak Kumar;Choudhury, Arun Kumar;Baliarsinha, Anoj Kumar
目的和目的：研究父母糖尿病史对2型糖尿病（T2DM）患者一级亲属炎症标志物、胰岛素抵抗、肥胖指数和颈动脉内膜中层厚度（cIMT）的影响。 材料和方法：将年龄为FH阳性的20-40岁T2DM患者的正常糖耐量（NGT）一级亲属纳入横断面研究。根据父母的糖尿病史，他们被分为三组：父亲家族史阳性（FHfather）、母亲家族史阳性（FHmother）和两者家族史阳性（FHboth）。年龄、性别和 BMI 匹配的对照组（其父母没有任何糖尿病史，被指定为 FH 阴性）进行比较。所有受试者都接受了详细的临床评估和生化研究。通过超声检查评估cIMT和内脏脂肪组织厚度（VAT）和皮下脂肪组织厚度（SAT）等肥胖指标。结果：FH母亲组和FH父亲组之间BMI、hsCRP、胰岛素抵抗程度、肥胖标志物和cIMT没有差异。与有单亲T2DM家族史的受试者相比，FH组受试者的胰岛素抵抗、亚临床炎症、动脉粥样硬化和肥胖指数均显着升高。结论：2型糖尿病患者一级亲属的hsCRP和cIMT显着高于对照组。与单亲有 T2DM 病史的个体相比，双亲都有 T2DM 病史的个体的血糖状况、cIMT 增加和不良心血管风险状况显着更差。 (C) 2017 年印度糖尿病。由爱思唯尔有限公司出版。保留所有权利。
Aim and objective: To study the effect of parental history of diabetes on markers of inflammation, insulin resistance, adiposity indices and carotid intima media thickness (cIMT) in first degree relatives of patients with type 2 diabetes mellitus (T2DM).Materials and methods: Normal glucose tolerant (NGT) first degree relatives of T2DM patients of age group 20-40 years designated as FHpositive were enrolled in the cross sectional study. Depending on the parental history of diabetes they were divided into three groups: family history positive in father (FHfather), family history positive in mother (FHmother) and family history positive in both (FHboth). Age, sex and BMI matched controls without any history of diabetes in their parents designated as FHnegative were taken for comparison. All subjects underwent detailed clinical evaluation and biochemical investigations. cIMT and adiposity indices like visceral adipose tissue thickness (VAT) and subcutaneous adipose tissue thickness (SAT) were assessed using ultrasonography.Results: No difference existed with regards to BMI, hsCRP, degree of insulin resistance, adiposity markers and cIMT between FHmother and FHfather group. Subjects in FHboth group had significantly higher degree of insulin resistance, subclinical inflammation, increased atherosclerosis and adiposity indices in contrast to those who have a single parent T2DM family history.Conclusions: hsCRP and cIMT are significantly higher in the first degree relatives of type2 diabetes mellitus patients than controls. Individuals with history of T2DM in both parents have significantly worse glycemic status, increased cIMT and adverse cardiovascular risk profile than those with T2DM history in only single parent. (C) 2017 Diabetes India. Published by Elsevier Ltd. All rights reserved.