Melatonin Can Modulate Neurodegenerative Diseases by Regulating Endoplasmic Reticulum Stress.
Melatonin Can Modulate Neurodegenerative Diseases by Regulating Endoplasmic Reticulum Stress.
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DOI：
10.3390/ijms24032381
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发表时间：
2023-01-25
影响因子：
5.6
通讯作者：
Joo, Seong Soo
中科院分区：
文献类型：
--
作者：
Yoo, Yeong-Min;Joo, Seong Soo
随着人们年龄的增长，他们患上退行性疾病的风险通常会增加，如癌症、糖尿病、帕金森病（PD）、阿尔茨海默病（AD）、类风湿性关节炎和骨质疏松症。全世界数百万人随着年龄的增长而患上这些疾病。在大多数国家，神经退行性疾病通常被认为是困扰老年人的头号原因。内质网（ER）应激被认为与人类的一些神经系统疾病，如PD和AD有关。褪黑激素是一种主要由松果体合成的神经内分泌激素，具有调节昼夜节律、增强免疫力、抗氧化、抗衰老、抗肿瘤等多种生物学功能。尽管有很多关于褪黑激素预防或抑制疾病的论文，但关于褪黑激素对神经元ER应激和神经退行性疾病的影响的论文却很少。本文旨在总结和介绍褪黑激素的作用，重点是它对神经元和神经退行性疾病的影响与ER应激。研究表明，褪黑激素ER应激的主要靶分子是CHOP，PERK和GRP 78/BiP是次要靶分子。因此，褪黑激素在保护神经元和治疗神经退行性变对抗ER应激中至关重要。
As people age, their risks of developing degenerative diseases such as cancer, diabetes, Parkinson’s Disease (PD), Alzheimer’s Disease (AD), rheumatoid arthritis, and osteoporosis are generally increasing. Millions of people worldwide suffer from these diseases as they age. In most countries, neurodegenerative diseases are generally recognized as the number one cause afflicting the elderly. Endoplasmic reticulum (ER) stress has been suggested to be associated with some human neurological diseases, such as PD and AD. Melatonin, a neuroendocrine hormone mainly synthesized in the pineal gland, is involved in pleiotropically biological functions, including the control of the circadian rhythm, immune enhancement, and antioxidant, anti-aging, and anti-tumor effects. Although there are many papers on the prevention or suppression of diseases by melatonin, there are very few papers about the effects of melatonin on ER stress in neurons and neurodegenerative diseases. This paper aims to summarize and present the effects of melatonin reported so far, focusing on its effects on neurons and neurodegenerative diseases related to ER stress. Studies have shown that the primary target molecule of ER stress for melatonin is CHOP, and PERK and GRP78/BiP are the secondary target molecules. Therefore, melatonin is crucial in protecting neurons and treating neurodegeneration against ER stress.
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