A helping hand from proteoglycans
A helping hand from proteoglycans
复制标题
蛋白多糖的帮助
DOI：
10.1016/0960-9822(91)90296-9
复制
发表时间：
1991
期刊：
影响因子：
9.2
通讯作者：
J. Massagué
中科院分区：
文献类型：
--
作者：
J. Massagué
生长因子是分泌的多肽，其在发育组织中指导细胞增殖、分化和组织化。生长因子作用的中心事件是它们与靶细胞质膜上的信号转导受体结合。这种相互作用是高度调节和多样化的;单个生长因子可能以各种亚型存在，这些亚型与多种受体亚型结合，每种受体亚型具有独特的亲和力和信号传导特性。环境特异性和细胞特异性的表达模式的因素和受体决定了他们的可用性彼此。该系统还受到生长因子与某些功能上不同于信号受体的结合分子相互作用的能力的调节。这些分子中的一些是参与生长因子转运或清除的循环蛋白。其他包括一系列新发现的细胞表面和细胞周分子，它们结合生长因子，如碱性成纤维细胞生长因子（bFGF）和转化生长因子-[3]（TGF-[3]），并明显调节它们与信号受体的接触。这些结合组分的特别兴趣不仅在于它们的生物学性质，而且在于它们是蛋白聚糖的事实，蛋白聚糖通常在细胞生物学家感兴趣的分子的等级中排名不高。蛋白聚糖是高度糖基化的蛋白质，其携带硫酸化的糖胺聚糖（GAG）作为主要的碳水化合物链，并且是软骨的丰富组分，骨和间质组织基质，它们在其中发挥重要的结构作用。对细胞膜和细胞周围基质中发现的各种低丰度蛋白聚糖的结构和作用知之甚少。Yayon等人最近的一份报告，[1]然而，在证明某些细胞表面蛋白聚糖是不可缺少的方面，
Growth factors are secreted polypeptides that guide cell proliferation, differentiation and organization in developing tissues. The central event in the action of growth factors is their binding to signal-transducing receptors on the plasma membrane of target cells. This interaction is highly regulated and diversified; a single growth factor may exist in various isoforms that bind to multiple receptor subtypes each with distinctive affinity and signaling properties. Context-specific and cellspecific expression patterns of factors and receptors determine their availability to each other. The system is further regulated by the ability of growth factors to interact with certain binding molecules that are functionally distinct from the signaling receptors. Some of these molecules are circulating proteins that participate in growth factor transport or clearance. Others include a newly identified series of cell-surface and pericellular molecules that bind growth factors, such as basic fibroblast growth factor (bFGF) and transforming growth factor-] 3 (TGF-[3), and apparently regulate their access to signaling receptors. The particular interest of these binding components lies not only in their biological properties but also in the fact that they are proteoglycans, which have not usually ranked high in the pecking order of molecules of interest to cell biologists.Proteoglycans are highly glycosylated proteins that carry sulfated glycosaminoglycans (GAGs) as the principal carbohydrate chains and are abundant components of cartilage, bone and interstitial tissue matrices where they play important structural roles. Much less is known about the structure and role of various low-abundance proteoglycans that are found in cell membranes and in pericellular matrices. A recent report byYayon et al.,[1], however, represents significant progress in this area in demonstrating that certain cell-surface proteoglycans are indispens-
影响因子：
56.9
作者：
LEE, PL;JOHNSON, DE;WILLIAMS, LT
通讯作者：
WILLIAMS, LT
转化生长因子-β (TGF-β) 受体蛋白聚糖。
DOI：
--
发表时间：
1989
期刊：
The Journal of biological chemistry
影响因子：
--
作者：
Cheifetz,S;Massagué,J
通讯作者：
Massagué,J