Pediatric OCD structural brain deficits in conflict monitoring circuits: A voxel-based morphometry study
Pediatric OCD structural brain deficits in conflict monitoring circuits: A voxel-based morphometry study
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DOI：
10.1016/j.neulet.2007.05.047
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发表时间：
2007-06-29
影响因子：
2.5
通讯作者：
Vilarroya, Oscar
中科院分区：
文献类型：
--
作者：
Carmona, Susanna;Bassas, Nuria;Vilarroya, Oscar
本研究的目的是使用一种基于体素的形态测量方案，比较18名强迫症（OCD）儿童与性别和利手相匹配的健康儿童的大脑。用1.5-T MRI扫描仪采集图像，空间归一化，并用优化的基于体素的形态测量方案进行分割。与对照组相比，强迫症儿童的灰质（GM）总体积减少了5.93%。我们确定了强迫症脑容量减少的区域，已广泛相关的行动监测和错误信号的过程。具体而言，我们发现额叶（在家庭明智错误（FEW），多重比较校正后显着）和扣带回区域的双侧GM减少，以及双侧额叶和右顶叶的白色物质（WM）减少（p < 0.001未校正）。此外，我们发现强迫症组的症状严重程度与双侧海马GM体积之间呈负相关（p < 0.001未校正），年龄与GM左尾状核体积之间呈正相关（p=0.037 FWE小体积校正）。作为一个结论，我们的研究结果指出，冲突监测结构脑区的主要缺陷，在儿童强迫症，和纹状体异常的年龄相关的缺陷。(c)2007爱思唯尔爱尔兰有限公司保留所有权利。
The aim of this study is to use a voxel-based morphometry protocol to compare the brains of 18 children with obsessive-compulsive disorder (OCD) with those of a healthy group matched for gender and handedness. Images were acquired with a 1.5-T MRI scanner, spatially normalized, and segmented with an optimized voxel-based morphometry protocol. OCD children presented a 5.93% reduction of gray matter (GM) total volume in comparison with control brains. We identified OCD brain volume reductions in regions that have been extensively related to action monitoring and error signaling processes. Specifically, we found decreased bilateral GM in frontal (significant after Family Wise Error (FEW), multiple comparisons correction) and cingulate regions as well as decreased white matter (WM) in bilateral frontal and right parietal (p < 0.001 uncorrected). Additionally, we found a negative correlation between symptom severity and bilateral hippocampal GM-volume (p < 0.001 uncorrected) as well as a positive correlation between age and GM left caudate volume (p=0.037 FWE small volume corrected) in the OCD group. As a conclusion, our results point to conflict monitoring structural brain regions as primary deficits in pediatric OCD, and to striatal abnormalities as age-related deficits. (c) 2007 Elsevier Ireland Ltd. All rights reserved.