A prospective study of the relationship between serum vitamins A and E and risk of breast cancer.
A prospective study of the relationship between serum vitamins A and E and risk of breast cancer.
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DOI：
10.1038/bjc.1988.45
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发表时间：
1988-02
影响因子：
8.8
通讯作者：
Bulbrook, R D
中科院分区：
文献类型：
--
作者：
Russell, M J;Thomas, B S;Bulbrook, R D
在一项关于乳腺癌的8年前瞻性研究（1977-1985）中，从居住在根西岛的5，086名妇女中采集了血液，并将血清储存在-20 ℃下。在此期间，30名妇女患上了这种疾病，并对她们的血清样本进行了维生素A和E以及视黄醇结合蛋白（RBP）的分析。对另外288份年龄匹配的对照血清（每个癌前病例最多10份）进行了类似的分析。没有发现任何这些物质与乳腺癌的后续发展之间的关系。年龄增长与维生素A（r = 0.46，P <0.001）和RBP（r = 0.36，P <0.001）浓度呈显著相关。随着年龄的增长，维生素E的血液浓度也有增加的趋势，但这并不显著。血清RBP与维生素A浓度高度相关（r = 0.91，P <0.0001）。
In an 8 year prospective study (1977-1985) on breast cancer, blood was taken from 5,086 women resident in Guernsey, and the serum stored at -20 degrees C. During this period 30 women developed the disease and their serum samples were analysed for vitamins A and E, and for retinol-binding protein (RBP). A further 288 age-matched control sera (up to 10 per pre-cancer case) were similarly analysed. No relationship was found between any of these substances and subsequent development of breast cancer. A significant correlation between increasing age and vitamin A (r = 0.46, P less than 0.001) and RBP (r = 0.36, P less than 0.001) concentrations was observed. There was also a trend for increased blood concentrations of vitamin E with age, but this was not significant. Serum RBP and vitamin A concentrations were highly correlated (r = 0.91, P less than 0.0001).