Event-related potentials in posttraumatic headache
Event-related potentials in posttraumatic headache
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DOI：
10.1046/j.1526-4610.2001.041006579.x
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发表时间：
2001-06-01
期刊：
影响因子：
5
通讯作者：
Gallai, V
中科院分区：
文献类型：
--
作者：
Alberti, A;Sarchielli, P;Gallai, V
目的-评估由于轻微的颅脑损伤而导致的创伤后头痛患者的认知功能受损，这些患者没有涉及中枢神经系统的器质性损害。-术语创伤后综合征定义了创伤性脑损伤后的一组刻板的症状，这些症状是主观的和多种多样的。认知功能的缺陷和学习、注意力和短期记忆的快速过程的损害经常被发现。此外，头痛是患者报告的最常见的症状。由于症状的性质，定义创伤后综合征的很大局限性在于缺乏方法和诊断工具来量化主观障碍和证据表明中枢神经系统在这种病理条件下受累。方法-25名受试者(女性16人，男性9人；平均年龄28±9岁)在创伤事件发生后3至6个月内接受检查。P300事件相关电位用奇数球范式和声学方式记录。结果：创伤后综合征患者双侧中央电极(Cz和Pt)的P300潜伏期平均较对照组延长(P<；.001)；假设平均+/-2SD为正常和异常结果的分界点，有13例(52%)P300潜伏期改变。Zung焦虑量表评分与P3波潜伏期之间的关系(r=0.46，P<；.02)。结论：这些数据表明P300事件相关电位在评估创伤后综合征患者的认知障碍方面是有用的。这类患者的认知潜力的改变，即使在没有神经成像可检测到的损害的情况下，也表明在创伤事件后可能发生的特定大脑区域的功能损害。
Objectives-To assess impairment of cognitive functions occurring in patients with posttraumatic headache as a consequence of a minor cranial trauma in the absence of organic damage involving the central nervous system.Background.-The term posttraumatic syndrome defines a stereotypic set of symptoms following traumatic brain injury that are subjective and varied. A deficit of cognitive function and impairment of the rapid processes of learning, attention, and short-term memory have frequently been identified. Moreover, headache is the most frequent symptom reported by the patients.Due to the nature of the symptoms, a great limitation in defining the posttraumatic syndrome is represented by the lack of methods and diagnostic tools that allow quantification of the subjective disturbances and evidence of the signs indicative of central nervous system involvement in this pathological condition.Methods.-Twenty-five subjects (16 women, 9 men; mean age, 28 +/- 9 years) were examined between 3 and 6 months after the traumatic event. The P300 event-related potential was recorded by an odd-ball paradigm with an acoustic modality. The patients underwent electroencephalography and brain stem auditory evoked potentials; magnetic resonance imaging was performed to exclude the presence of cerebral lesions.Results.-The mean latency of P300 was increased in both central electrodes (Cz and Pt) in patients with posttraumatic syndrome compared with controls (P < .001); assuming the value of mean +/- 2 SD was the cutoff point between normal and abnormal results, the P300 latency results were altered in 13 patients (52%).In the patient group, a significant correlation was demonstrated between Zung Depression Scale score and P3 and N2 wave latencies (r = 0.54, P < .004; r = 0.56, P < .003) and between Zung Anxiety Scale scores and P3 wave latencies (r = 0.46, P < .02).Conclusions.-These data suggest the usefulness of the P300 event-related potential in evaluating cognitive disturbances in patients affected by posttraumatic syndrome. Alteration of cognitive potential in such patients, even in the absence of lesions detectable by neuroimaging, indicate the functional impairment of specific cerebral areas that can occur after a traumatic event.