Biliary excretion and cerebrospinal fluid partition of perfluorooctanoate and perfluorooctane sulfonate in humans
Biliary excretion and cerebrospinal fluid partition of perfluorooctanoate and perfluorooctane sulfonate in humans
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DOI：
10.1016/j.etap.2007.04.003
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发表时间：
2007-09-01
影响因子：
4.3
通讯作者：
Koizumi, Akio
中科院分区：
文献类型：
--
作者：
Harada, Kouji H.;Hashida, Shuhei;Koizumi, Akio
全氟辛烷磺酸（PFOS）和全氟辛酸（PFOA）在环境中被检测到，更具体地说，在野生动物和人类中被检测到。报道的全氟辛烷磺酸和全氟辛烷磺酸生物半衰期的巨大差异仍未得到探索。在这项研究中，我们旨在评估它们在人体内从血清到胆汁和脑脊液（CSF）的分离。患者捐献血清和胆汁4对，血清和脑脊液7对。在考虑胆汁排泄时，血清样本中PFOA和PFOS的中位数浓度分别为3.8和23.2 ng/mL，而胆汁样本中PFOA和PFOS的中位数浓度分别为1.0和27.9 ng/mL。全氟辛烷磺酸（PFOS）浓度中位数比（胆汁/血清：0.60）显著高于全氟辛烷磺酸（PFOA）的0.21 （p < 0.01）。在本研究中，PFOA和PFOS的胆道排泄率分别为1.06和2.98 mL/kg/天，显著高于人类通过尿液的血清清除率，可能是一种主要的排泄途径。PFOA和PFOS的胆道重吸收率分别为0.89和0.97。在考虑进入脑脊液时，血清样品中PFOA和PFOS的中位数浓度分别为2.6和18.4 ng/mL，而脑脊液样品中PFOA和PFOS的中位数浓度分别为0.06和0.10 ng/mL。PFOS浓度的中位数比值(CSF/血清：9.1 （x 10(-3)）与PFOA的17.6 （x 10(-3)）相当，表明PFOA和PFOS不能自由穿过血脑屏障。总之，这些化合物在大鼠和人类的胆道排泄是相似的，人类的半衰期长可能是由于尿液中排泄水平低和胆道重吸收率高。(c) 2007 Elsevier B.V.版权所有
Perfluorooctane sulfonate (PFOS) and perfluorooctanoate (PFOA) are detected in the environment and, more specifically, in wildlife and humans. The large variation in the reported biological half-lives for PFOA and PFOS has remained unexplored. In this study, we aimed to evaluate their partition from serum to bile and cerebrospinal fluid (CSF) in humans. Four pairs of serum and bile, and 7 pairs of serum and CSF were donated by patients. In considering biliary excretion, the median concentrations of PFOA and PFOS in serum samples were 3.8 and 23.2 ng/mL, respectively, whereas those in bile samples were 1.0 and 27.9 ng/mL, respectively. The median ratio of PFOS concentrations (bile/serum: 0.60) was significantly higher than that for PFOA, 0.21 (p < 0.01). Biliary excretion rates for PFOA and PFOS in the present study subjects were estimated as 1.06 and 2.98 mL/kg/day, respectively, which is significantly higher than serum clearances via urine in humans and might represent a major excretion route. Biliary reabsorption rates of PFOA and PFOS were estimated to be 0.89 and 0.97, respectively. In considering partition into the cerebrospinal fluid, the median concentrations of PFOA and PFOS in serum samples were 2.6 and 18.4 ng/mL, respectively, whereas those in CSF samples were 0.06 and 0.10 ng/mL, respectively. The median ratio of PFOS concentrations (CSF/serum: 9.1 (x 10(-3))) was comparable to that of PFOA, 17.6 (X 10(-3)), suggesting that PFOA and PFOS cannot pass through the blood-brain barrier freely. In conclusion, the biliary excretion of these compounds was comparable in both rats and humans and the long half-lives in humans might be attributable to low levels of excretion in urine and high biliary reabsorption rates. (c) 2007 Elsevier B.V. All rights reserved.