Biological stress response terminology: Integrating the concepts of adaptive response and preconditioning stress within a hormetic dose-response framework
Biological stress response terminology: Integrating the concepts of adaptive response and preconditioning stress within a hormetic dose-response framework
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DOI：
10.1016/j.taap.2007.02.015
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发表时间：
2007-07-01
影响因子：
3.8
通讯作者：
Mattson, Mark P.
中科院分区：
文献类型：
--
作者：
Calabrese, Edward J.;Bachmann, Kenneth A.;Mattson, Mark P.
许多定期评估剂量-反应关系的生物学分支学科已经确定了一个进化上保守的过程，其中低剂量的应激刺激激活了适应性反应，增加了细胞或生物体对中度至重度应激水平的抵抗力。由于科学家在这些领域缺乏频繁的互动，出现了广泛的术语来描述这种剂量-反应关系。这种情况已经成为问题，因为不同的术语描述了一系列相似的生物反应（例如，适应性反应、预适应、兴奋效应），不利地影响跨学科交流，甚至可能模糊可概括的特征和中心生物学概念。在广泛学科的科学家的支持下，本文提供了一系列建议，我们相信这些建议可以在剂量反应术语中实现更大的概念和谐，以及更好地理解和沟通广泛的生物学科。(c)2007年爱思唯尔公司All rights reserved.
Many biological subdisciplines that regularly assess dose-response relationships have identified an evolutionarily conserved process in which a low dose of a stressful stimulus activates an adaptive response that increases the resistance of the cell or organism to a moderate to severe level of stress. Due to a lack of frequent interaction among scientists in these many areas, there has emerged a broad range of terms that describe such dose-response relationships. This situation has become problematic because the different terms describe a family of similar biological responses (e.g., adaptive response, preconditioning, hormesis), adversely affecting interdisciplinary communication, and possibly even obscuring generalizable features and central biological concepts. With support from scientists in a broad range of disciplines, this article offers a set of recommendations we believe can achieve greater conceptual harmony in dose-response terminology, as well as better understanding and communication across the broad spectrum of biological disciplines. (c) 2007 Elsevier Inc. All rights reserved.