Cobalt Precursors for High-Throughput Discovery of Base Metal Asymmetric Alkene Hydrogenation Catalysts
Cobalt Precursors for High-Throughput Discovery of Base Metal Asymmetric Alkene Hydrogenation Catalysts
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DOI：
10.1126/science.1243550
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发表时间：
2013-11-29
期刊：
影响因子：
56.9
通讯作者：
Chirik, Paul J.
中科院分区：
文献类型：
--
作者：
Friedfeld, Max R.;Shevlin, Michael;Chirik, Paul J.
烯烃的不对称氢化是制备单一对映体化合物的最广泛使用的方法之一，特别是在医药和农业化学工业中。四十多年来，含有铑、铱和钌的贵金属络合物主要用作催化剂。在这里，我们报告了一组简单的钴前体的手性膦配体库的快速评估。从这些研究中，贱金属预催化剂已被发现用于氢化具有高对映体过量的官能化和非官能化烯烃，证明了更多地球丰富的金属在不对称氢化中的潜在效用。
Asymmetric hydrogenation of alkenes is one of the most widely used methods for the preparation of single enantiomer compounds, especially in the pharmaceutical and agrochemical industries. For more than four decades, precious metal complexes containing rhodium, iridium, and ruthenium have been predominantly used as catalysts. Here, we report rapid evaluation of libraries of chiral phosphine ligands with a set of simple cobalt precursors. From these studies, base metal precatalysts have been discovered for the hydrogenation of functionalized and unfunctionalized olefins with high enantiomeric excesses, demonstrating the potential utility of more earth-abundant metals in asymmetric hydrogenation.