MicroRNA regulation of cardiovascular development.
MicroRNA regulation of cardiovascular development.
复制标题
DOI：
10.1161/circresaha.108.192872
复制
发表时间：
2009-03-27
影响因子：
20.1
通讯作者：
Srivastava D
中科院分区：
文献类型：
--
作者：
Cordes KR;Srivastava D
心血管发育的转录调控需要基因表达的精确时空控制，而转录因子的杂合突变经常与人类心血管畸形有关。一种涉及小型非编码 microRNA (miRNA) 转录后调节的新机制已成为许多心源性过程的中心调节因子。我们开始了解 miRNA 在细胞增殖、分化、凋亡、应激反应和肿瘤发生等重要生物过程中发挥的功能。对特定心脏和血管细胞类型中表达的 miRNA 的鉴定发现了这些小 RNA 在心肌细胞分化、细胞周期、传导、血管形成以及成人心脏肥大阶段期间的重要调节作用。在这里，我们概述了心血管发育中 miRNA 调节的最新发现，并通过揭示其 mRNA 靶点来报告了解其功能的最新进展。对心血管发育过程中 miRNA 功能的进一步分析将使我们能够确定基于 miRNA 的新型治疗策略的潜力。
The transcriptional regulation of cardiovascular development requires precise spatiotemporal control of gene expression, and heterozygous mutations of transcription factors has frequently been implicated in human cardiovascular malformations. A novel mechanism involving posttranscriptional regulation by small, noncoding microRNAs (miRNAs) has emerged as a central regulator of many cardiogenic processes. We are beginning to understand the functions that miRNAs play during essential biological processes, such as cell proliferation, differentiation, apoptosis, stress response, and tumorigenesis. The identification of miRNAs expressed in specific cardiac and vascular cell types has led to the discovery of important regulatory roles for these small RNAs during cardiomyocyte differentiation, cell cycle, conduction, vessel formation, and during stages of cardiac hypertrophy in the adult. Here, we overview the recent findings on miRNA regulation in cardiovascular development and report the latest advances in understanding their function by unveiling their mRNA targets. Further analysis of miRNA function during cardiovascular development will allow us to determine the potential for novel miRNA-based therapeutic strategies.