G-protein-coupled receptor Gpr1 and G-protein Gpa2 of cAMP-dependent signaling pathway are involved in glucose-induced pexophagy in the yeast Saccharomyces cerevisiae
G-protein-coupled receptor Gpr1 and G-protein Gpa2 of cAMP-dependent signaling pathway are involved in glucose-induced pexophagy in the yeast Saccharomyces cerevisiae
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DOI：
10.1016/j.cellbi.2007.11.001
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发表时间：
2008-05-01
影响因子：
3.9
通讯作者：
Sibirny, Andriy A.
中科院分区：
文献类型：
--
作者：
Nazarko, Volodymyr Y.;Thevelein, Johan M.;Sibirny, Andriy A.
在酵母细胞中，葡萄糖在遗传和代谢水平上引起细胞代谢的各种变化。这种变化之一是发生在液泡中的过氧化物酶体的自噬降解（自噬）。我们已经发现，在酿酒酵母中，G-蛋白偶联受体Gpr 1和G-蛋白Gpa 2的缺陷，cAMP信号通路的组件，强烈抑制葡萄糖诱导的基质过氧化物酶体蛋白硫解酶的降解。我们的结论是蛋白Gpr 1和Gpa 2参与葡萄糖传感和信号转导过程中的酵母pexophagy过程。(C)2007年国际细胞生物学联合会。由爱思唯尔有限公司出版。保留所有权利。
In yeast cell, glucose induces various changes of cellular metabolism on genetic and metabolic levels. One of such changes is autophagic degradation of dispensable peroxisomes (pexophagy) which occurs in vacuoles. We have found that in Saccharomyces cerevisiae, defect of G-protein-coupled receptor Gpr1 and G-protein Gpa2, both the components of cAMP-signaling pathway, strongly suppressed glucose-induced degradation of matrix peroxisomal protein thiolase. We conclude that proteins Gpr1 and Gpa2 are involved in glucose sensing and signal transduction during pexophagy process in yeast. (C) 2007 International Federation for Cell Biology. Published by Elsevier Ltd. All rights reserved.