Quantification of gastric emptying caused by impaired coordination of pyloric closure with antral contraction: a simulation study
Quantification of gastric emptying caused by impaired coordination of pyloric closure with antral contraction: a simulation study
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DOI：
10.1098/rsif.2019.0266
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发表时间：
2019-08-01
影响因子：
3.9
通讯作者：
Imai, Yohsuke
中科院分区：
文献类型：
--
作者：
Ishida, Shunichi;Miyagawa, Taimei;Imai, Yohsuke
胃运动功能的适当协调是胃排空健康的必要条件。然而，幽门功能可能因功能障碍或外科手术而受损。在这里，我们展示幽门闭合和心房收缩之间的协调如何影响液体内容物的排空。我们使用解剖学上真实的胃肠道几何结构数值模拟流体动力学。胃近端蠕动收缩导致胃排空速度为3- 8ml / min（-1）。当幽门无法关闭时，排空率增加至10- 30ml min(-1)，在胃窦松弛期间发生十二指肠向胃窦的瞬时逆行血流。如果幽门在终末胃窦收缩期开始打开，则排空迅速，如果幽门仅在胃窦松弛期打开，则排空率为负。我们的研究结果表明，胃窦收缩和幽门关闭之间的协调性受损可导致胃排空延迟、胃排空快速和胆汁反流。
Proper coordination of gastric motor functions is required for healthy gastric emptying. However, pyloric function may be impaired by functional disorders or surgical procedures. Here, we show how coordination between pyloric closure and antral contraction affects the emptying of liquid contents. We numerically simulated fluid dynamics using an anatomically realistic gastrointestinal geometry. Peristaltic contractions in the proximal stomach resulted in gastric emptying at a rate of 3-8 ml min(-1). When the pylorus was unable to close, the emptying rate increased to 10-30 ml min(-1), and instantaneous retrograde flow from the duodenum to the antrum occurred during antral relaxation. Rapid emptying occurred if the pylorus began to open during the terminal antral contraction, and the emptying rate was negative if the pylorus only opened during the antral relaxation phase. Our results showed that impaired coordination between antral contraction and pyloric closure can result in delayed gastric emptying, rapid gastric emptying and bile reflux.