Catalytic Activity Dependency on Catalyst Components in Aerobic Copper-TEMPO Oxidation
Catalytic Activity Dependency on Catalyst Components in Aerobic Copper-TEMPO Oxidation
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DOI：
10.1002/chem.200901245
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发表时间：
2009-01-01
影响因子：
4.3
通讯作者：
Koskinen, Ari M. P.
中科院分区：
文献类型：
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作者：
Kumpulainen, Esa T. T.;Koskinen, Ari M. P.
考察了铜-TEMPO（2，2，6，6-四甲基哌啶N-氧化物）催化剂组分对醇类有氧氧化反应的影响。碱的种类和用量对反应活性有很大影响。联吡啶配体浓度对催化没有重大影响，但过量会导致活性降低，反应时间延长。发现克里思的ne动力学依赖性为1.15，铜的ne动力学依赖性为2.25，这是双核催化体系的指示。各种烯丙醇和脂肪醇的优化条件提供了良好的快速氧化。
The influence of catalyst components in the copper-TEMPO (2,2,6,6-tetramethylpiperidine N-oxide) catalysed aerobic oxidation of alcohols was investigated. The type and amount of base greatly influences reactivity. The bipyridyl ligand concentration had no major influence on catalysis, but excessive amounts led to a decrease in activity for longer reaction times. ne kinetic dependency for TEMPO was found to be 1.15, and for copper 2.25, which is an indication of a binuclear catalytic system. Optimised conditions with various allylic and aliphatic alcohols give good to excellent rapid oxidations.