Update on the oxidative stress theory of aging: does oxidative stress play a role in aging or healthy aging?
Update on the oxidative stress theory of aging: does oxidative stress play a role in aging or healthy aging?
复制标题
DOI：
10.1016/j.freeradbiomed.2009.12.015
复制
发表时间：
2010-03-01
影响因子：
7.4
通讯作者：
Perez, Viviana I.
中科院分区：
文献类型：
--
作者：
Salmon, Adam B.;Richardson, Arlan;Perez, Viviana I.
衰老的氧化应激理论预测，改变氧化应激/损伤的操作将改变衰老。确定衰老是否改变的黄金标准是寿命，即，改变氧化应激/损伤会改变寿命吗？在抗氧化防御系统中进行遗传操作的小鼠旨在直接解决这一预测，除了少数例外，寿命没有变化。然而，当这些转基因/基因敲除小鼠使用发展各种类型的年龄相关的病理模型进行测试时，它们显示出由氧化应激理论预测的病理进展和/或严重程度的改变;增加的氧化应激加速病理，减少的氧化应激延缓病理。这些相互矛盾的观察结果可能意味着a）氧化应激在衰老中发挥非常有限的作用，如果有的话，但在健康寿命中发挥主要作用;和/或B）氧化应激在衰老中发挥的作用取决于环境。在最小压力的环境中，正如在最佳饲养条件下所预期的那样，氧化损伤在衰老中起的作用很小。然而，在慢性应激下，包括减少最佳健康的病理表型，氧化应激/损伤在衰老中起着重要作用。在这些条件下，增强的抗氧化防御发挥“抗衰老”作用，导致寿命，年龄相关的病理学和生理功能的变化，如衰老的氧化应激理论所预测的。
The oxidative stress theory of aging predicts that manipulations that alter oxidative stress/damage will alter aging. The gold standard for determining whether aging is altered is lifespan, i.e., does altering oxidative stress/damage change lifespan? Mice with genetic manipulations in the antioxidant defense system designed to directly address this prediction have, with few exceptions, shown no change in lifespan. However, when these transgenic/knockout mice are tested using models that develop various types of age-related pathology, they show alterations in progression and/or severity of pathology as predicted by the oxidative stress theory; increased oxidative stress accelerates pathology and reduced oxidative stress retards pathology. These contradictory observations might mean a) oxidative stress plays a very limited, if any, role in aging but a major role in healthspan; and/or b) the role that oxidative stress plays in aging depends on environment. In environments with minimal stress, as expected under optimal husbandry, oxidative damage plays little role in aging. However, under chronic stress, including pathological phenotypes that diminish optimal health, oxidative stress/damage plays a major role in aging. Under these conditions, enhanced antioxidant defenses exert an “anti-aging” action, leading to changes in lifespan, age-related pathology, and physiological function as predicted by the oxidative stress theory of aging.
登录
查看更多内容
影响因子：
15.9
作者：
Anderson, Ethan J.;Lustig, Mary E.;Neufer, P. Darrell
通讯作者：
Neufer, P. Darrell
DOI：
10.1152/ajplung.00191.2002
发表时间：
2003-04-01
影响因子：
4.9
作者：
Bowler, RP;Arcaroli, J;Crapo, JD
通讯作者：
Crapo, JD
影响因子：
7.8
作者：
Andziak, Blazej;Buffenstein, Rochelle
通讯作者：
Buffenstein, Rochelle
影响因子：
3.3
作者：
BARJA, G;CADENAS, S;LOPEZTORRES, M
通讯作者：
LOPEZTORRES, M
影响因子：
4.4
作者：
Berkowitz BA;Gradianu M;Bissig D;Kern TS;Roberts R
通讯作者：
Roberts R