N-halamine-decorated electrospun polyacrylonitrile nanofibrous membranes: characterization and antimicrobial properties
N-halamine-decorated electrospun polyacrylonitrile nanofibrous membranes: characterization and antimicrobial properties
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DOI：
10.1016/j.reactfunctpolym.2021.105058
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发表时间：
2021-10-01
影响因子：
5.1
通讯作者：
Yan, Fei
中科院分区：
文献类型：
--
作者：
Cervantes, Martha Y. Garcia;Han, Li;Yan, Fei
饮用水和空气的微生物污染是一个令人震惊的现象，引起了全球越来越多的关注。尽管多年来在微生物消毒方面取得了许多进展，但仍然迫切需要强大，快速，廉价和可现场部署的策略来解决这一公共卫生问题。在此，我们报告的抗菌纳米纤维膜的制备，其中包括高度多孔的电纺聚丙烯腈（PAN）膜与1-氯-2，2，5，5-四甲基-4-咪唑烷酮（MC）通过两种不同的方法，即共混电纺和浸泡。采用扫描电子显微镜、傅里叶变换红外光谱和滴定法对功能化膜进行表征，并对两种细菌（肺炎克雷伯氏菌和大肠杆菌）进行抗菌效果评价。MC修饰的静电纺丝PAN膜在2分钟的接触时间内灭活了两种细菌菌株。此外，MC浸渍PAN膜对气溶胶E.暴露30分钟后的大肠杆菌。简单，成本效益，多功能性，和电纺丝过程的可扩展性，连同N-卤胺的上级抗菌活性，使其成为一个有前途的解决方案，水消毒，空气中的微生物的灭活。
Microbial contamination of drinking water and air is an alarming phenomenon that has attracted increasing global attention. Although many advances in microbial disinfection have been made over the years, robust, rapid, inexpensive and field-deployable strategies are still urgently needed to address this public health issue. Herein we report the preparation of antimicrobial nanofibrous membranes, which involves incorporation of highly porous electrospun polyacrylonitrile (PAN) membranes with 1-chloro-2,2,5,5-tetramethyl-4-imidazolidi-none (MC) by two different approaches, namely, blend electrospinning and soaking. The functionalized mem-branes were characterized using scanning electron microscopy, Fourier transform infrared spectroscopy, and titrimetry, and their antimicrobial efficacies were evaluated against two bacteria (Klebsiella pneumoniae and Escherichia coli). The MC-decorated electrospun PAN membranes inactivated both bacterial strains within 2 min of contact time. Moreover, the MC-soaked PAN membrane showed excellent disinfection efficacy against aero-solized E. coli after an exposure of 30 min. The simplicity, cost-effectiveness, versatility, and scalability of the electrospinning process, together with the superior antimicrobial activity of N-halamines make it a promising solution for water disinfection, and for the inactivation of airborne microorganisms.