Incidence and severity of keratoconus in Asir province, Saudi Arabia
Incidence and severity of keratoconus in Asir province, Saudi Arabia
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DOI：
10.1136/bjo.2005.074955
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发表时间：
2005-11-01
影响因子：
4.1
通讯作者：
Murphy, PJ
中科院分区：
文献类型：
--
作者：
Assiri, AA;Yousuf, BI;Murphy, PJ
目的：评估沙特阿拉伯阿西尔省圆锥角膜患者的发病率及相关体征和症状。方法：125例新发圆锥角膜患者（男51例，女74例），平均年龄18.5岁（SD 3.8）；年龄在8 - 28岁之间)，从阿西尔中心医院眼科的转诊中招募，为期1年。记录年龄、视力、角膜测量以及临床体征和症状。结果：阿西尔省圆锥角膜发病率为每10万人20例。此外，疾病的严重程度也很高，表现为较早的平均年龄（17.7（3.6）岁）和晚期圆锥角膜。无论是戴眼镜还是硬隐形眼镜，98%的眼睛的视力都达到了6/12或更高。超过一半（56%）的患者患有特应性眼病。16%的患者有阳性的家族病史，16%的患者患有特应性皮炎（湿疹和/或白癜风）。结论：圆锥角膜在沙特阿拉伯阿西尔省的发病率和严重程度较高，发病早，且在年轻时发展到严重阶段的速度较快。这可能反映了遗传和/或环境因素对圆锥角膜病因的影响。
Aim: To assess the incidence and associated signs and symptoms of patients with keratoconus in Asir Province, Saudi Arabia.Methods: 125 new keratoconus patients ( 51 male, 74 female; mean age 18.5 (SD 3.8) years; range 8 - 28 years) were recruited from referrals to the department of ophthalmology, Asir Central Hospital, over a 1 year period. Age, visual acuity, and keratometry were recorded along with clinical signs and symptoms.Results: The incidence of keratoconus in Asir Province is 20 cases per 100 000 population. Also, the disease severity is high, as indicated by an early mean age (17.7 (3.6) years) with advanced stage keratoconus. Visual acuity, with either spectacles or rigid contact lenses, was 6/12 or better in 98% of eyes measured. Just over half (56%) of patients had atopic ocular disease. 16% of patients had a positive family history of the disease and 16% had atopic dermatitis ( eczema and/ or vitiligo).Conclusion: The incidence and severity of keratoconus in Asir Province, Saudi Arabia, is high with an early onset and more rapid progress to the severe disease stage at a young age. This might reflect the influence of genetic and/ or environmental factor(s) in the aetiology of keratoconus.