Insight into the Effect of Ligands on the Optical Properties of Germanium Quantum Dots and Their Applications in Persistent Cell Imaging
Insight into the Effect of Ligands on the Optical Properties of Germanium Quantum Dots and Their Applications in Persistent Cell Imaging
复制标题
深入了解配体对锗量子点光学性质的影响及其在持久细胞成像中的应用
DOI：
10.1021/acs.langmuir.0c02477
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发表时间：
2020-10-20
期刊：
影响因子：
3.9
通讯作者：
Li, Haitao
中科院分区：
文献类型：
--
作者：
Lu, Qiujun;Dong, Hu;Li, Haitao
锗量子点由于其大的量子限域效应和良好的生物相容性在荧光应用中显示出独特的优势。然而，GeQD在精确控制荧光发射方面面临困难。这一缺陷给理解GeQDs的荧光机制带来了挑战，并限制了GeQDs的潜在应用。本文采用化学还原法合成了一系列平均粒径约为2.6nm的不同配体修饰的GeQDs。通过调节表面配体，GeQDs的荧光发射可以从蓝色变为黄绿色。通过实验和理论计算，深入研究了表面配体对GeQDs荧光发射的影响。此外，合成的GeQDs具有良好的生物相容性和光稳定性，可以作为高性能的荧光探针用于长期的荧光生物成像。这一工作为深入理解GeQDs的荧光机制提供了一个良好的基础，并将在不久的将来促进GeQDs的各种有前途的应用。
Germanium quantum dots (GeQDs) show unique advantages in fluorescence applications due to their large quantum confinement effect and excellent biocompatibility. However, GeQDs are confronted with difficulty in accurately controlling the fluorescence emission. This defect brings challenges to understanding the fluorescence mechanism and limits the potential applications of GeQDs. In this paper, a series of GeQDs with the average diameter of about 2.6 nm modified with different ligands were synthesized by the chemical reduction method. The fluorescence emission of GeQDs can be changed from blue to yellow-green through adjusting the surface ligands. The influence of surface ligands on the fluorescence emission of GeQDs was thoroughly investigated by experimental and theoretical calculations. Furthermore, the synthesized GeQDs exhibit good biocompatibility and photostability and can act as high-performance fluorescence probes for long-term fluorescent bioimaging. This work provides a good and deep understanding of the fluorescence mechanism of GeQDs and will facilitate diverse promising applications of GeQDs in the near future.