Implantable optical fibers for immunotherapeutics delivery and tumor impedance measurement.
Implantable optical fibers for immunotherapeutics delivery and tumor impedance measurement.
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DOI：
10.1038/s41467-021-25391-z
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发表时间：
2021-08-26
影响因子：
16.6
通讯作者：
Tong R
中科院分区：
文献类型：
--
作者：
Chin AL;Jiang S;Jang E;Niu L;Li L;Jia X;Tong R
免疫检查点阻断抗体具有很有前景的临床应用，但存在诸如严重毒性和中等患者应答率的缺点。目前的递送策略，包括旨在避免全身毒性的局部给药，都不能在数周内持续供应药物;调整药物剂量以降低全身毒性或增强治疗反应是不可能的。在这里，我们开发了一种植入式微型化设备，使用电极嵌入式光纤，在几周的时间内具有局部递送和测量能力。通过该装置递送的局部免疫检查点阻断抗体与光动力疗法的组合在多种肿瘤模型中增强了持续的抗肿瘤免疫力。我们的设备使用肿瘤阻抗测量来及时呈现治疗结果，并允许修改递送的药物及其浓度，使得该设备可能用于按需递送强效免疫治疗剂而不会加剧毒性。免疫检查点阻断抗体具有有希望的临床应用，但具有严重的毒性和中等的应答率。在这里，作者提出了一种电极嵌入式植入式光纤装置，具有局部输送和肿瘤阻抗测量能力，可安全地引发持久的抗肿瘤免疫力。
Immune checkpoint blockade antibodies have promising clinical applications but suffer from disadvantages such as severe toxicities and moderate patient–response rates. None of the current delivery strategies, including local administration aiming to avoid systemic toxicities, can sustainably supply drugs over the course of weeks; adjustment of drug dose, either to lower systemic toxicities or to augment therapeutic response, is not possible. Herein, we develop an implantable miniaturized device using electrode-embedded optical fibers with both local delivery and measurement capabilities over the course of a few weeks. The combination of local immune checkpoint blockade antibodies delivery via this device with photodynamic therapy elicits a sustained anti-tumor immunity in multiple tumor models. Our device uses tumor impedance measurement for timely presentation of treatment outcomes, and allows modifications to the delivered drugs and their concentrations, rendering this device potentially useful for on-demand delivery of potent immunotherapeutics without exacerbating toxicities. Immune checkpoint blockade antibodies have promising clinical applications, but suffer from severe toxicities and moderate response rates. Here the authors present an electrode-embedded, implantable optical fiber device with both local delivery and tumor impedance measurement capabilities to safely elicit durable anti-tumor immunity.
影响因子：
10.8
作者：
Tian B;Shankarappa SA;Chang HH;Tong R;Kohane DS
通讯作者：
Kohane DS