Detection of myocardial capillary orientation with intravascular iron-oxide nanoparticles in spin-echo MRI.
Detection of myocardial capillary orientation with intravascular iron-oxide nanoparticles in spin-echo MRI.
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在旋转回声 MRI 中用血管内氧化铁纳米颗粒检测心肌毛细血管方向。
DOI：
10.1002/mrm.20827
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发表时间：
2006
影响因子：
3.3
通讯作者：
Wen,Han
中科院分区：
文献类型：
--
作者：
Vignaud,Alexandre;Rodriguez,Ignacio;Ennis,DanielB;DeSilva,Ranil;Kellman,Peter;Taylor,Joni;Bennett,Eric;Wen,Han
在哺乳动物的心脏中，毛细血管与肌肉纤维紧密排列。我们报道了在血管内氧化铁纳米造影剂(CA)--Ferumoxtran-10存在的情况下，在心脏的MR自旋回波(SE)图像中观察到的主场方向相关的对比。我们描述了一种新的MRI方法来绘制心肌壁毛细血管的优先方向。与R2松弛速率张量的最小本征值对应的特征向量与毛细管网络的预期取向一致。初步结果也证明了该方法在活体应用于啮齿动物成像的可行性。Magn Reson Med，2006。发布日期：#2006 Wiley-Liss，Inc.
In mammalian hearts the capillaries are closely aligned with the muscle fibers. We report our observation of a main‐field direction‐dependent contrast in MR spin‐echo (SE) images of the heart in the presence of Ferumoxtran‐10, an intravascular iron‐oxide nanoparticle contrast agent (CA). We describe a novel MRI method for mapping the preferential orientation of capillaries in the myocardial wall. The eigenvector corresponding to the minimum eigen value of theR2relaxation rate tensor is consistent with the expected orientation of the capillary network. Preliminary results also demonstrate the feasibility of this method for in vivo application to rodent imaging. Magn Reson Med, 2006. Published © 2006 Wiley‐Liss, Inc.