Glycosylation as a marker for inflammatory arthritis
Glycosylation as a marker for inflammatory arthritis
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DOI：
10.3233/cbm-130373
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发表时间：
2014-01-01
影响因子：
3.1
通讯作者：
Rudd, Pauline M.
中科院分区：
文献类型：
--
作者：
Albrecht, Simone;Unwin, Louise;Rudd, Pauline M.
血清蛋白糖基化的变化在炎症性关节炎中发挥重要作用。由于类风湿性关节炎的破坏性，免疫球蛋白 G (IgG) 半乳糖基化的改变引起了特别关注。研究血清蛋白的糖基化变化已被认为是一种潜在策略，可为炎症性关节炎疾病的诊断、病因病理学和治疗提供附加价值。这些研究领域面临的关键问题是糖基化是否可以用作疾病分化、诊断、预测病程和严重程度以及评估疾病治疗的补充临床前和临床标志物。这些研究主要集中在 TNF 拮抗剂上，它为治疗炎症性关节炎提供了一种新的、有前景的方法。最近推出的新型高通量糖分析工具可以对大型患者群体进行更深入、更有效的研究，并有助于获得对潜在疾病途径的复杂机制的新见解。
Changes in serum protein glycosylation play an important role in inflammatory arthritis. Altered galactosylation of immunoglobulin G (IgG) in rheumatoid arthritis attracts special attention due to the devastating nature of the disease. Studying glycosylation changes of serum proteins has been recognized as a potential strategy to provide added value regarding diagnostics, aetiopathology and therapy of inflammatory arthritic diseases. Key questions, which are approached in these fields of research, are whether or not glycosylation can be used as a complementary pre-clinical and clinical marker for disease differentiation, diagnosis, the prediction of disease course and severity as well as for the evaluation of disease therapies. These studies mainly focus on TNF antagonists, which present a new and promising way of treating inflammatory arthritis. The recent availability of new high-throughput glycoanalytical tools enables a more profound and efficient investigation in large patient cohorts and helps to gain new insights in the complex mechanism of the underlying disease pathways.