Safety and Characterization of a Novel Multi-channel TMS Stimulator
Safety and Characterization of a Novel Multi-channel TMS Stimulator
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DOI：
10.1016/j.brs.2013.09.004
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发表时间：
2014-03-01
影响因子：
7.7
通讯作者：
Zangen, Abraham
中科院分区：
文献类型：
--
作者：
Roth, Yiftach;Levkovitz, Yechiel;Zangen, Abraham
目的：介绍一种新型方便的多通道刺激器的生理功能，该刺激器由5个通道组成，每个通道的刺激参数可独立控制。方法：在健康志愿者中测试各通道的同步和顺序操作。研究了不同刺激间间隔(ISIS)的配对脉冲方案对手部APB和腿部AH肌肉的影响。将4个通道同时运行时的能量消耗和线圈加热率与单个8字形线圈进行了比较。结果：显示了不同刺激参数下单独通道的重复运行。各种通道的操作可以同时或顺序组合，以产生分辨率为AS的ISIS的多个脉冲。发现了作为ISI函数的抑制和促进的普遍模式，并对线圈配置和脉冲宽度有一定的依赖性。发现诱导抑制强烈依赖于条件化脉冲和测试脉冲的相对取向。结果表明，该方法能够在脑浅层区域诱导抑制，而在深层区域不能诱导抑制，从而使效应集中在脑深层。与标准的单通道8字形线圈相比，多个通道同时工作的能量消耗显著降低，线圈加热减少。结论：多通道刺激器可以在不同通道中使用不同的刺激模式，对不同的大脑区域同步诱导不同的兴奋性调制。采用不同深度分布的线圈进行多脉冲操作，可增加TMS效应在脑深部区域的焦点。(C)2014 Elsevier Inc.保留所有权利。
Background: Currently available TMS stimulators have a single channel operating a single coil.Objective: To outline and present physical and physiological benefits of a novel convenient multi-channel stimulator, comprising five channels, where the stimulation parameters of each channel are independently controllable.Methods: Simultaneous and sequential operation of various channels was tested in healthy volunteers. Paired pulses schemes with various inter-stimulus intervals (ISIs) were studied for the hand APB and the leg AH muscles. Energy consumption and coil heating rates with simultaneous operation of 4 channels was compared to a single figure-8 coil.Results: Repetitive operation of separate channels with different stimulation parameters is demonstrated. The operations of various channels can be combined simultaneously or sequentially to induce multiple pulses with ISIs of as resolution. A universal pattern of inhibition and facilitation as a function of ISI was found, with some dependence on coils configurations and on pulse widths. A strong dependence of the induced inhibition on the relative orientation of the conditioning and test pulses was discovered. The ability of this method to induce inhibition in shallow brain region but not in deeper region, thus focusing the effect in the deep brain region, is demonstrated. A significant saving in energy consumption and a reduction in coil heating were demonstrated for several channels operated simultaneously compared to a standard single channel figure-8 coil.Conclusions: The multi-channel stimulator enables the synchronized induction of different excitability modulations to different brain regions using different stimulation patterns in various channels. Multiple pulses operation with coils with various depth profiles can increase the focality of TMS effect in deep brain regions. (C) 2014 Elsevier Inc. All rights reserved.