Effects of alpha-chlorohydrin and related compounds on the reproductive organs and fertility of the male rat.
Effects of alpha-chlorohydrin and related compounds on the reproductive organs and fertility of the male rat.
复制标题
α-氯醇和相关化合物对雄性大鼠生殖器官和生育能力的影响。
DOI：
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发表时间：
1974
期刊：
影响因子：
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通讯作者：
H. Jackson
中科院分区：
文献类型：
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作者：
E. R. Cooper;A. Jones;H. Jackson
总结。比较了\g=a\-氯丙烷、\g=a\-溴丙烷、外氯丙烷和甘醇对雄性大鼠生殖道的抗生育作用和组织病理学变化。与先前的报道相反，\g=a\-溴丙烷诱导大鼠双侧精索和永久性不育，但没有\g=a\-氯丙烷的功能性附睾绝育作用。甘油三酯复制了g=a -氯丙烷的原始灭菌效果，但对附睾近端头的病变没有作用。环氧氯丙烷的活性与\g=a\-氯丙烷相似。附睾头近端原发病变特别累及“圆锥”和邻近区域，伴有上皮脱落。这可能会损害该区域的分泌/吸收功能，从而对薄壁滤管造成严重损害。除肉芽肿形成外，上皮均有恢复。近头的根尖区域在整个过程中保持完好。
Summary. The antifertility effects and histopathological changes in the reproductive tract of male rats following administration of \g=a\-chloro-hydrin, \g=a\-bromohydrin,epi-chlorohydrin and glycidol were compared. Contrary to earlier reports, \g=a\-bromohydrin induced bilateral spermatocoeles and permanent sterility in rats but did not produce the functional epididymal sterilizing effect of \g=a\-chlorohydrin. Glycidol reproduced the primary sterilizing effect of \g=a\-chlorohydrin but not the lesions in the proximal caput epididymidis. Epi-chlorohydrin showed activities resembling those of \g=a\-chlorohydrin. The primary lesion in the proximal caput epididymidis was seen specifically to involve the `conus' and adjacent regions with sloughing of the epithelium. This may impair the secretory/absorptive function of this region with ensuing severe damage to the thin-walled ductuli efferentes. Except where granulomata were formed, restoration of the epithelium occurred. The apical region of the proximal caput remained undamaged throughout.