Leptin levels in serum depending on Body Mass Index in patients with endometrial hyperplasia and cancer
Leptin levels in serum depending on Body Mass Index in patients with endometrial hyperplasia and cancer
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DOI：
10.1016/j.ejogrb.2006.08.012
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发表时间：
2008-01-01
影响因子：
2.6
通讯作者：
Rzepka-Gorska, Izabella
中科院分区：
文献类型：
--
作者：
Cymbaluk, Aneta;Chudecka-Glaz, Anita;Rzepka-Gorska, Izabella
目的：瘦素（一种由白色脂肪组织分泌的激素）的浓度与体重密切相关。瘦素与其他几种激素相互作用，改变一些酶和促炎细胞因子的活性，参与造血、生热和血管生成，并参与碳水化合物和脂质代谢的控制。本研究旨在确定患有子宫内膜增生和癌症的肥胖患者的血清瘦素浓度是否偏离正常子宫内膜患者的值。 研究设计：我们招募了 86 名肥胖绝经后妇女，其中 40 名患有子宫内膜癌和增生，46 名患有正常子宫内膜。根据 BMI，形成三个亚组： I < 30； II=30-40； III > 40。使用 IBL 的免疫酶测试试剂盒测量瘦素浓度。使用卡方 (chi(2)) 检验和 Statistica 软件包进行统计比较。 结果：子宫内膜癌和增生患者的瘦素平均血清浓度为 16737.1 pg/ml，而无子宫内膜病理的患者为 9048.7 pg/ml (p < 0.0001)。值得注意的是，与对照组相比，每个 BMI 子宫内膜病理患者亚组的瘦素浓度均较高 (p < 0.005)。结论：瘦素似乎参与了子宫内膜的增殖过程。肥胖是子宫内膜癌的重要危险因素。 (c) 2006 年，爱思唯尔爱尔兰有限公司出版。
Objectives: Concentrations of leptin, a hormone secreted by white adipose tissue, correlate strongly with body mass. Leptin interacts with several other hormones, modifies the activities of some enzymes and proinflammatory cytokines, participates in hematopoiesis, thermogenesis, and angiogenesis, and is involved in the control of carbohydrate and lipid metabolism. This study was undertaken to determine whether serum concentrations of leptin in obese patients with endometrial hyperplasia and cancer deviate from values in patients with normal endometrium.Study design: We enrolled 86 obese postmenopausal women, including 40 with endometrial cancer and hyperplasia and 46 with normal endometrium. Depending on BMI, three subgroups were formed: I < 30; II = 30-40; III > 40. Leptin concentrations were measured with immunoenzymatic test kits from IBL. Statistical comparison was done with the chi square (chi(2)) test and Statistica software package.Results: Mean serum concentration of leptin in endometrial cancer and hyperplasia was 16737.1 pg/ml as opposed to 9048.7 pg/ml in patients without endometrial pathology (p < 0.0001). Significantly, higher concentrations of leptin were noted in every BMI subgroup of patients with endometrial pathology in comparison to controls (p < 0.005).Conclusions: Leptin appears to participate in proliferative processes of the endometrium. Obesity is an important risk factor in endometrial cancer. (c) 2006 Published by Elsevier Ireland Ltd.