Cancer organoid applications to investigate chemotherapy resistance.
Cancer organoid applications to investigate chemotherapy resistance.
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癌症器官的应用以研究化疗抗性。
DOI：
10.3389/fmolb.2022.1067207
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发表时间：
2022
影响因子：
5
通讯作者：
中科院分区：
文献类型：
--
作者：
在临床实践中，很大一部分癌症患者接受化疗，但肿瘤持续存在或获得耐药性;消除这一障碍可能有助于降低癌症相关死亡人数。癌症研究的所有领域都越来越多地使用类器官技术，这是一种在体外模拟体内环境的培养技术，特别是在快速发展的抗癌药物耐药性，耐药持续者和药物筛选领域。本文综述了类器官技术，类器官在抗癌药物耐药性研究领域的应用，它们与临床信息和临床试验的相关性，以及自动化和高通量的方法。
In clinical practice, a large proportion of cancer patients receive chemotherapy, yet tumors persist or acquire resistance; removing this obstacle could help to lower the number of cancer-related fatalities. All areas of cancer research are increasingly using organoid technology, a culture technique that simulates the in vivo environment in vitro, especially in the quickly developing fields of anticancer drug resistance, drug-tolerant persisters, and drug screening. This review provides an overview of organoid technology, the use of organoids in the field of anticancer drug resistance research, their relevance to clinical information and clinical trials, and approaches to automation and high throughput.