Maternal health in pregnancy and intellectual disability in the offspring: A population-based study
Maternal health in pregnancy and intellectual disability in the offspring: A population-based study
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DOI：
10.1016/j.annepidem.2005.05.002
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发表时间：
2006-06-01
影响因子：
5.6
通讯作者：
Bower, Carol
中科院分区：
文献类型：
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作者：
Leonard, Helen;De Klerk, Nick;Bower, Carol
目的：探讨常见母体疾病与子代不明原因智力障碍(ID)的关系。方法：采用记录链接的方法，获取有和无ID儿童的母亲健康信息。结果：患有哮喘母亲的孩子患轻中度ID的风险增加(OR=1.5 2；可信区间[CI]=1.2 6~1.831)，糖尿病(OR=1.6 9；CI=1.2 6~2.2 7)，肾脏或尿路疾病(OR=2.0 9；CI，1.39~3.14)和癫痫(OR，3.53；CI，2.56~4.84)。患有糖尿病(OR，2.89；CI，1.28-6.51)和癫痫(OR，4.5 7；CI，1.69-12.31)的妇女的子女患ASD的风险增加。对于贫血(n=1101)，患严重缺铁性贫血的风险增加(OR，5.26；CI，2.16-12.80)。结论：患有哮喘和糖尿病等疾病的母亲的子女患缺铁性贫血的风险增加对弱势或少数民族人群尤其重要，对他们来说，这些疾病更普遍，而且可能不太好管理。
PURPOSE: The aim of the study is to investigate the relationship between common maternal conditions and intellectual disability (ID) of unknown cause in the offspring.METHODS: Information about the maternal health of children with and without ID was obtained by using record linkage. For mothers with specific medical conditions, proportions of children with mild to moderate ID, severe ID, and autism spectrum disorder (ASD) with ID were compared with those who did not have ID.RESULTS: There was an increased risk for mild to moderate ID in children of mothers with asthma (odds ratio [OR], 1.52; confidence interval [CI], 1.26-1.831), diabetes (OR, 1.69; CI, 1.26-2.27), a renal or urinary condition (OR, 2.09; CI, 1.39-3.14), and epilepsy (OR, 3.53; CI, 2.56-4.84). ASD risk was increased for children of women with diabetes (OR, 2.89; CI, 1.28-6.51) and epilepsy (OR, 4.5 7; CI, 1.69-12.3 1). For anemia (n = 1101), there was an increased risk for severe ID (OR, 5.26; CI, 2.16-12.80).CONCLUSIONS: The increased risk for ID in offspring of mothers with such conditions as asthma and diabetes is particularly important for disadvantaged or ethnic populations, for whom these conditions are more prevalent and may be less well managed.