Triptolide: pharmacological spectrum, biosynthesis, chemical synthesis and derivatives.
Triptolide: pharmacological spectrum, biosynthesis, chemical synthesis and derivatives.
复制标题
雷公藤甲素：药理谱、生物合成、化学合成及衍生物
作者：
Gao J;Zhang Y;Liu X;Wu X;Huang L;Gao W
雷公藤内酯醇是从雷公藤中分离得到的松香烷型二萜。F.、具有显著的药理活性。研究结果表明，雷公藤内酯醇对多种实体瘤有明显的抑制作用。因此，雷公藤内酯醇已成为下一个“重磅炸弹”药物的先导化合物候选者之一，多种雷公藤内酯醇衍生物已进入临床研究。越来越多的研究者开发了雷公藤内酯醇的合成方法以满足临床需要。本文从雷公藤内酯醇的药理活性、生物合成途径、化学合成途径等方面，综述了近20年来雷公藤内酯醇衍生物的毒理学和临床研究进展，以期为不同学科的研究者提供新的思路，使不同学科的研究者能够更有效地解决科学问题。为后来的研究者从多方面研究雷公藤内酯醇奠定了基础。
Triptolide, an abietane-type diterpenoid isolated from Tripterygium wilfordii Hook. F., has significant pharmacological activity. Research results show that triptolide has obvious inhibitory effects on many solid tumors. Therefore, triptolide has become one of the lead compounds candidates for being the next "blockbuster" drug, and multiple triptolide derivatives have entered clinical research. An increasing number of researchers have developed triptolide synthesis methods to meet the clinical need. To provide new ideas for researchers in different disciplines and connect different disciplines with researchers aiming to solve scientific problems more efficiently, this article reviews the research progress made with analyzes of triptolide pharmacological activity, biosynthetic pathways, and chemical synthesis pathways and reported in toxicological and clinical studies of derivatives over the past 20 years, which have laid the foundation for subsequent researchers to study triptolide in many ways.