Toward Better Genetically Encoded Sensors of Membrane Potential.
Toward Better Genetically Encoded Sensors of Membrane Potential.
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DOI：
10.1016/j.tins.2016.02.005
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发表时间：
2016-05
影响因子：
15.9
通讯作者：
Baker BJ
中科院分区：
文献类型：
--
作者：
Storace D;Sepehri Rad M;Kang B;Cohen LB;Hughes T;Baker BJ
Genetically encoded optical sensors of cell activity are powerful tools that can be targeted to specific cell types. This is especially important in neuroscience because individual brain regions can include a multitude of different cell types. Optical imaging allows for simultaneous recording from numerous neurons or brain regions. Optical signals of membrane potential are useful because membrane potential changes are a direct sign of both synaptic and action potentials. Here we describe recent improvements in the in vitro and in vivo signal size and kinetics of genetically encoded voltage indicators (GEVIs) and discuss their relationship to alternative sensors of neural activity.
