Epigenetic mechanisms in neurological disease.
Epigenetic mechanisms in neurological disease.
复制标题
作者：
对脑表观基因组的探索，包括各种类型的DNA甲基化和共价组蛋白修饰，为正常神经发育、神经疾病和衰老的机制提供了前所未有的新见解。传统上，大脑中的染色质缺陷被认为是在罕见遗传综合征的背景下发生的早期发育的静态损害，但现在很明显，表观遗传机制的突变和适应不良涵盖了更广泛的连续体，包括成人起病的神经退行性疾病。在这里，我们描述了神经表观遗传学的最新进展如何有助于改善对发育和退行性脑疾病的机制理解，以及它们如何影响这些疾病未来治疗方法的发展。
The exploration of brain epigenomes, which consist of various types of DNA methylation and covalent histone modifications, is providing new and unprecedented insights into the mechanisms of normal neural development, neurological disease and aging. Traditionally, chromatin defects in brain were considered static lesions of early development that occurred in the context of rare genetic syndromes but it is now clear that mutations and maladaptations of the epigenetic machinery cover a much wider continuum, including adult-onset neurodegenerative disease. Here, we describe how recent advances in neuroepigenetics have contributed to an improved mechanistic understanding of developmental and degenerative brain disorders, as well as how they could influence the development of future therapies for these conditions.