Functional MRI studies of spatial and nonspatial working memory
Functional MRI studies of spatial and nonspatial working memory
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DOI：
10.1016/s0926-6410(98)00004-4
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发表时间：
1998-07-01
期刊：
影响因子：
--
通讯作者：
Lease, J
中科院分区：
文献类型：
--
作者：
D'Esposito, M;Aguirre, GK;Lease, J
对猴子进行的单单位记录显示，在信息呈现和随后的行为使用之间的延迟期间，外侧前额叶皮层的神经元会增加其放电。基于猴子的损伤和神经生理学研究，已经提出外侧前额叶皮层的背侧区域是必要的空间信息的临时存储，而更腹侧的区域是必要的非空间信息的维持。然而，功能性神经影像学研究并没有清楚地证明人类的这种分裂。我们在这里提出了一个分析所有报告的人类功能神经影像学研究绘制到一个标准化的大脑。这项分析没有发现前额叶皮层的背侧/腹侧细分取决于工作记忆中保存的材料类型的证据，但提出了半球组织（即，左非空间;右空间）。我们还进行了功能MRT研究16名正常受试者在两个任务，旨在探测无论是非空间或空间工作记忆，分别。一组和亚组分析显示，在空间和非空间[工作记忆控制]减法中，右侧额中回（Brodmann区46）的激活位置相似。基于前额叶组织的另一个模型[M. Petrides，额叶和行为，Cur。Opin.神经生物学，4（1994）207-211]，对先前的成像文献数据的重新考虑表明，前额叶皮层的背侧/腹侧细分可能取决于对工作记忆中保存的信息执行的处理类型。(C)1998 Elsevier Science B. V.保留所有权利。
Single-unit recordings in monkeys have revealed neurons in the lateral prefrontal cortex that increase their firing during a delay between the presentation of information and its later use in behavior. Based on monkey lesion and neurophysiology studies, it has been proposed that a dorsal region of lateral prefrontal cortex is necessary for temporary storage of spatial information whereas a more ventral region is necessary for the maintenance of nonspatial information. Functional neuroimaging studies, however, have not clearly demonstrated such a division in humans. We present here an analysis of all reported human functional neuroimaging studies plotted onto a standardized brain. This analysis did not find evidence for a dorsal/ventral subdivision of prefrontal cortex depending on the type of material held in working memory, but a hemispheric organization was suggested (i.e., left-nonspatial; right-spatial). We also performed functional MRT studies in 16 normal subjects during two tasks designed to probe either nonspatial or spatial working memory, respectively. A group and subgroup analysis revealed similarly located activation in right middle frontal gyrus (Brodmann's area 46) in both spatial and nonspatial [working memory-control] subtractions. Based on another model of prefrontal organization [M. Petrides, Frontal lobes and behavior, Cur. Opin. Neurobiol., 4 (1994) 207-211], a reconsideration of the previous imaging Literature data suggested that a dorsal/ventral subdivision of prefrontal cortex may depend upon the type of processing performed upon the information held in working memory. (C) 1998 Elsevier Science B.V. All rights reserved.