The ankyrin repeat protein diego mediates Frizzled-dependent planar polarization
The ankyrin repeat protein diego mediates Frizzled-dependent planar polarization
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DOI：
10.1016/s1534-5807(01)00010-7
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发表时间：
2001-07-01
影响因子：
11.8
通讯作者：
Eaton, S
中科院分区：
文献类型：
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作者：
Feiguin, F;Hannus, M;Eaton, S
在果蝇翅膀上皮的平面极化过程中，亲水性黏附分子Flamingo响应Frizzled信号定位于近/远端细胞边界；扰动Frizzled信号改变了Flamingo的分布，许多细胞直径相距很远，其机制尚不清楚。这项工作鉴定了一个组织极性基因Diego，它由六个Ankyrin重复序列组成，并与Flamingo在近/远端边界上共存。迭戈对于火烈鸟的极化积累是特别需要的，当过度表达时，它会驱动火烈鸟的异位聚集。我们的数据表明，Frizzleed通过Diego促进了Flamingo的局部聚集，而Diego和Flamingo在一个细胞中的聚集非自主地传播到其他细胞。
During planar polarization of the Drosophila wing epithelium, the homophilic adhesion molecule Flamingo localizes to proximal/distal cell boundaries in response to Frizzled signaling; perturbing Frizzled signaling alters Flamingo distribution, many cell diameters distant, by a mechanism that is not well understood. This work identifies a tissue polarity gene, diego, that comprises six ankyrin repeats and colocalizes with Flamingo at proximal/distal boundaries. Diego is specifically required for polarized accumulation of Flamingo and drives ectopic clustering of Flamingo when overexpressed. Our data suggest that Frizzled acts through Diego to promote local clustering of Flamingo, and that clustering of Diego and Flamingo in one cell nonautonomously propagates to others.