Estrogen profiles in postmenopausal African-American women in a wheat bran fiber intervention study.
Estrogen profiles in postmenopausal African-American women in a wheat bran fiber intervention study.
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麦麸纤维干预研究中绝经后非洲裔美国妇女的雌激素概况。
DOI：
10.1080/01635589809514693
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发表时间：
1998
期刊：
影响因子：
--
通讯作者：
Wu,X
中科院分区：
文献类型：
--
作者：
Stark,AH;Switzer,BR;Atwood,JR;Travis,RG;Smith,JL;Ullrich,F;Ritenbaugh,C;Hatch,J;Wu,X
高膳食纤维摄入量被假设可以降低血液雌激素浓度，这一效应被认为有利于降低乳腺癌风险。本研究调查了参加社区干预试验的绝经后非洲裔美国妇女膳食补充麦麸与循环雌激素水平之间的关系。17名绝经后妇女（年龄63±1.6岁）参与了研究。在每天补充含有28毫克核黄素的35克麦麸谷物（11.6克不溶性膳食纤维）的饮食前后5至6周，评估营养状况，收集血液和24小时尿液样本。核黄素证实所有绝经后参与者都遵守了干预方案。17名绝经后妇女中有9名正在接受某种形式的雌激素替代疗法（PM‐ERT）。PM - ERT组的基线激素水平在饮食干预后没有显著变化。雌二醇（96.8±20.3 vs 113.8±23.3 pg/ml）、雄烯二酮（0.47±0.06 vs 0.45±0.06 ng/ml）和性激素结合球蛋白（SHBG, 107±13.5 vs 106.6±13.3 nmol/l）水平保持不变。在8名未接受外源性激素（PM）的绝经后妇女中，麦麸摄入与雌二醇（25.7±2.7 vs. 31.0±1.9 pg/ml）、雌酮（38.3±10.1 vs. 39.3±10.6 pg/ml）和雄烯二酮（0.78±0.08 vs. 0.68±0.11 ng/ml）水平的预测降低无关，也与SHBG浓度升高无关（35.2±6.4 vs. 34.8±6.5 nmol/l）。接受ERT治疗的受试者的基线和干预后雌二醇和SHBG水平显著高于未接受ERT治疗的受试者，雄烯二酮水平显著低于未接受ERT治疗的受试者。在PM或PM - ERT非裔美国参与者中，没有发现麦麸补充剂与激素水平之间的关联。这些对绝经后妇女的研究结果与早期对绝经前妇女的研究结果相反，这些研究表明麦麸纤维可以降低血清性激素。绝经后妇女的雌激素水平只有绝经前妇女的5-10%；因此，单靠高麦麸纤维饮食可能不足以进一步降低这些低水平。
High dietary fiber intake has been hypothesized to lower blood estrogen concentrations, an effect thought to be beneficial for decreasing breast cancer risk This study investigated the association between dietary supplementation of wheat bran and circulating estrogen levels in postmenopausal African‐American women participating in a community intervention trial. Seventeen postmenopausal women (aged 63 ± 1.6 yr) participated in the study. Nutritional status was assessed and blood and 24‐hour urine samples were collected before and after five to six weeks of daily supplementation of the diet with 35 g of wheat bran cereal (11.6 g insoluble dietary fiber) marked with 28 mg of riboflavin. Riboflavin confirmed that all postmenopausal participants adhered to the intervention protocol. Nine of the 17 postmenopausal women were taking some form of estrogen replacement therapy (PM‐ERT). Baseline hormone levels in the PM‐ERT group did not significantly change after the dietary intervention. Estradiol (96.8±20.3 vs. 113.8 ± 23.3 pg/ml), androstenedione (0.47 ± 0.06 vs. 0.45 ± 0.06 ng/ml), and sex hormone‐binding globulin (SHBG, 107 ± 13.5 vs. 106.6 ± 13.3 nmol/l) levels remained constant. In the eight postmenopausal women who were not receiving exogenous hormones (PM), wheat bran consumption was not associated with predicted decreased levels of estradiol (25.7 ± 2.7 vs. 31.0 ± 1.9 pg/ml), estrone (38.3 ± 10.1 vs. 39.3 ± 10.6 pg/ml), and androstenedione (0.78 ± 0.08 vs. 0.68 ±0.11 ng/ml) or with increased concentrations of SHBG (35.2 ± 6.4 vs. 34.8 ± 6.5 nmol/l). Participants receiving ERT had baseline and postin‐tervention levels of estradiol and SHBG significantly higher and androstenedione significantly lower than those not receiving ERT. No association between wheat bran supplementation and hormone levels was found in PM or PM‐ERT African‐American participants. These results in postmenopausal women are in contrast to findings of earlier studies in premenopausal women indicating that wheat bran fiber decreases serum sex hormones. Estrogen levels in postmenopausal women are only 5–10% of those in premenopausal women; therefore, a high wheat bran fiber diet alone may not be sufficient to depress these low levels even further.