Dysfunction of hippocampal interneurons in epilepsy
Dysfunction of hippocampal interneurons in epilepsy
复制标题
癫痫海马中间神经元功能障碍
DOI：
10.1007/s12264-014-1478-4
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发表时间：
2014-12-01
影响因子：
5.6
通讯作者：
Peng, Bi-Wen
中科院分区：
文献类型：
--
作者：
Liu, Yu-Qiang;Yu, Fang;Peng, Bi-Wen
含有γ-氨基丁酸（GABA）的中间神经元对大脑的发育和功能都至关重要。GABA能抑制的下调可能导致癫痫样活动的产生。中间神经元的缺失、轴突发芽和功能障碍被认为是癫痫发生的机制。最近的证据表明，网络连接和中间神经元的属性负责兴奋-抑制神经元回路。在癫痫变化期间，CA 1神经元回路中兴奋和抑制之间的平衡发生了相当大的改变。本文综述了中间神经元的多样性，癫痫中间神经元功能障碍的原因，以及使用GABA能神经元祖细胞治疗癫痫的可能性。
Gamma-amino-butyric acid (GABA)-containing interneurons are crucial to both development and function of the brain. Down-regulation of GABAergic inhibition may result in the generation of epileptiform activity. Loss, axonal sprouting, and dysfunction of interneurons are regarded as mechanisms involved in epileptogenesis. Recent evidence suggests that network connectivity and the properties of interneurons are responsible for excitatory-inhibitory neuronal circuits. The balance between excitation and inhibition in CA1 neuronal circuitry is considerably altered during epileptic changes. This review discusses interneuron diversity, the causes of interneuron dysfunction in epilepsy, and the possibility of using GABAergic neuronal progenitors for the treatment of epilepsy.