T2*mapping for articular cartilage assessment: principles, current applications, and future prospects
T2*mapping for articular cartilage assessment: principles, current applications, and future prospects
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DOI：
10.1007/s00256-014-1852-3
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发表时间：
2014-10-01
影响因子：
2.1
通讯作者：
Bittersohl, Bernd
中科院分区：
文献类型：
--
作者：
Hesper, Tobias;Hosalkar, Harish S.;Bittersohl, Bernd
随着旨在通过早期干预改变骨关节炎病程的关节保留手术的进展，对软骨状态进行准确可靠的评估至关重要。生物化学敏感的MRI技术可以为疾病的发作和进展添加强大的生物标志物，因此，可以成为诊断和随访软骨异常的有意义的评估工具。T2* 标测可能是一个很好的选择，因为它将联合收割机的优点，生化软骨评估显着的特点，包括成像时间短，高分辨率的三维软骨评估的能力，而不需要造影剂管理或特殊的硬件。已经报道了几项体外和体内研究，这些研究详细阐述了软骨T2* 评估在各种软骨疾病模式和退化等级中的潜力。然而，仍有许多有待理解的问题，某些未解决的问题已经变得明显，这些研究对进一步应用这项技术至关重要。本文综述了T2 ~* 成像技术的原理及其在关节软骨评价中的应用。最新研究的局限性进行了讨论，并提出了对病人护理的潜在影响。
With advances in joint preservation surgery that are intended to alter the course of osteoarthritis by early intervention, accurate and reliable assessment of the cartilage status is critical. Biochemically sensitive MRI techniques can add robust biomarkers for disease onset and progression, and therefore, could be meaningful assessment tools for the diagnosis and follow-up of cartilage abnormalities. T2* mapping could be a good alternative because it would combine the benefits of biochemical cartilage evaluation with remarkable features including short imaging time and the ability of high-resolution three-dimensional cartilage evaluation-without the need for contrast media administration or special hardware. Several in vitro and in vivo studies, which have elaborated on the potential of cartilage T2* assessment in various cartilage disease patterns and grades of degeneration, have been reported. However, much remains to be understood and certain unresolved questions have become apparent with these studies that are crucial to the further application of this technique. This review summarizes the principles of the technique and current applications of T2* mapping for articular cartilage assessment. Limitations of recent studies are discussed and the potential implications for patient care are presented.