Cardiac and plasma lipid profiles in response to acute hypoxia in neonatal and young adult rats.
Cardiac and plasma lipid profiles in response to acute hypoxia in neonatal and young adult rats.
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DOI：
10.1186/1476-511x-9-3
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发表时间：
2010-01-13
影响因子：
4.5
通讯作者：
Raff H
中科院分区：
文献类型：
--
作者：
Bruder ED;Raff H
新生儿对急性缺氧的生理和生化反应尚未完全确定。脂肪酸和脂质在心脏功能的大多数方面起着重要作用。我们进行了全面的脂质分析，调查发生在新生和年轻的成年大鼠缺氧2小时，并从缺氧恢复2小时的心脏组织和血浆中的变化。缺氧新生儿心脏和血浆中短链酰基肉毒碱和大多数血浆长链脂肪酸的浓度降低。缺氧恢复后，丙酰肉碱，棕榈酰肉碱，硬脂酰肉碱的浓度在新生儿心脏增加，而油基肉碱和亚油基肉碱浓度在新生儿血浆中增加。长链脂肪酸和长链酰基肉毒碱的浓度增加，在缺氧的年轻成年大鼠的心脏和血浆中，这些代谢产物恢复到基线值后，从缺氧。从新生大鼠到年轻成年大鼠，急性缺氧对心脏和血浆脂质谱的影响不同。缺氧期间新生儿心脏和血浆脂质谱的变化可能允许更大的代谢和生理灵活性，并增加生存机会。缺氧恢复后新生儿心脏脂质谱的持续改变可能在心律紊乱的发展中发挥作用。
The physiological and biochemical responses to acute hypoxia have not been fully characterized in neonates. Fatty acids and lipids play an important role in most aspects of cardiac function. We performed comprehensive lipid profiling analysis to survey the changes that occur in heart tissue and plasma of neonatal and young adult rats exposed to hypoxia for 2 h, and following 2 h of recovery from hypoxia. Cardiac and plasma concentrations of short-chain acylcarnitines, and most plasma long-chain fatty acids, were decreased in hypoxic neonates. Following recovery from hypoxia, concentrations of propionylcarnitine, palmitoylcarnitine, stearoylcarnitine were increased in neonatal hearts, while oleylcarnitine and linoleylcarnitine concentrations were increased in neonatal plasma. The concentrations of long-chain fatty acids and long-chain acylcarnitines were increased in the hearts and plasma of hypoxic young adult rats; these metabolites returned to baseline values following recovery from hypoxia. There are differential effects of acute hypoxia on cardiac and plasma lipid profiles with maturation from the neonate to the young adult rat. Changes to neonatal cardiac and plasma lipid profiles during hypoxia likely allowed for greater metabolic and physiologic flexibility and increased chances for survival. Persistent alterations in the neonatal cardiac lipid profile following recovery from hypoxia may play a role in the development of rhythm disturbances.