Sustained activation of c-Jun N-terminal and extracellular signal-regulated kinases in port-wine stain blood vessels.
Sustained activation of c-Jun N-terminal and extracellular signal-regulated kinases in port-wine stain blood vessels.
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DOI：
10.1016/j.jaad.2014.07.025
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发表时间：
2014-11
影响因子：
13.8
通讯作者：
Nelson JS
中科院分区：
文献类型：
--
作者：
Tan W;Chernova M;Gao L;Sun V;Liu H;Jia W;Langer S;Wang G;Mihm MC Jr;Nelson JS
Port-wine stain (PWS) is a congenital, progressive vascular malformation but the pathogenesis remains incompletely understood. We sought to investigate the activation status of various kinases, including extracellular signal-regulated kinase, c-Jun N-terminal kinase, AKT, phosphatidylinositol 3-kinase, P70 ribosomal S6 kinase, and phosphoinositide phospholipase C γ subunit, in PWS biopsy tissues. Immunohistochemistry was performed on 19 skin biopsy samples from 11 patients with PWS. c-Jun N-terminal kinase, extracellular signal-regulated kinase, and P70 ribosomal S6 kinase in pediatric and adult PWS blood vessels were consecutively activated. Activation of AKT and phosphatidylinositol 3-kinase was found in many adult hypertrophic PWS blood vessels but not in infants. Phosphoinositide phospholipase C γ subunit showed strong activation in nodular PWS blood vessels. Infantile PWS sample size was small. Our data suggest a subsequent activation profile of various kinases during different stages of PWS: (1) c-Jun N-terminal and extracellular signal-regulated kinases are firstly and consecutively activated in all PWS tissues, which may contribute to both the pathogenesis and progressive development of PWS; (2) AKT and phosphatidylinositol 3-kinase are subsequently activated, and are involved in the hypertrophic development of PWS blood vessels; and (3) phosphoinositide phospholipase C γ subunit is activated in the most advanced stage of PWS and may participate in nodular formation.
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DOI：
10.1056/nejmoa1213507
发表时间：
2013-05-23
期刊：
The New England journal of medicine
影响因子：
--
作者：
Shirley MD;Tang H;Gallione CJ;Baugher JD;Frelin LP;Cohen B;North PE;Marchuk DA;Comi AM;Pevsner J
通讯作者：
Pevsner J
影响因子：
13.8
作者：
Arbiser, JL;Weiss, SW;Cohen, C
通讯作者：
Cohen, C
影响因子：
4.1
作者：
Populo, Helena;Vinagre, Joao;Soares, Paula
通讯作者：
Soares, Paula
DOI：
10.1001/archderm.1953.01540030065006
发表时间：
1953-01-01
期刊：
AMA ARCHIVES OF DERMATOLOGY AND SYPHILOLOGY
影响因子：
--
作者：
PRATT, AG
通讯作者：
PRATT, AG