Implantable Systems for Continuous Liquorpheresis and CSF Replacement.
Implantable Systems for Continuous Liquorpheresis and CSF Replacement.
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DOI：
10.7759/cureus.1022
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发表时间：
2017-02-10
期刊：
影响因子：
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通讯作者：
Menéndez González M
中科院分区：
文献类型：
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作者：
Menéndez González M
液化脑病(脑脊液过滤)是一种治疗方法，已被提出用于治疗多种神经系统疾病，其中抗体、炎症介质或异常多肽是疾病的病因或在疾病的发病机制中发挥重要作用。连续性或间歇性脑脊液置换可能是迄今为止尚未探索的替代方法。在这里，我们回顾了以往在自身免疫性和退行性神经系统疾病中使用液体回输的经验。然后，我们描述了以前的技术报告，并提供了一些新的创新，以设计双向脑脊液分流系统，该系统可以用人工脑脊液沉积或脑脊液过滤器来补充，分别允许脑脊液置换或液体分离。这两种选择都会导致患者脑脊液的机械性稀释。
Liquorpheresis (cerebrospinal fluid filtration) comprises a therapeutical approach that has been proposed to treat several neurological conditions where antibodies, inflammatory mediators, or abnormal peptides are the cause or play an important role in the pathogenesis of the disease. Continuous or intermittent cerebrospinal fluid (CSF) replacement may be an alternative approach not explored thus far. Here, we review previous experiences in the use of liquorpheresis in autoimmune and degenerative neurological diseases. Then we describe previous technical reports and provide some new innovations in order to design bidirectional CSF shunting systems that can be complemented either with a deposit of artificial CSF or with a filter of CSF, allowing CSF replacement or liquorpheresis respectively. Both options would lead to mechanical dilution of the patient’s CSF.