P-Chiral Phosphine Sulfide Synthesis by Combination of Enzymatic Desymmetrization and Successive Deformylative P-C Cross-Couplings
P-Chiral Phosphine Sulfide Synthesis by Combination of Enzymatic Desymmetrization and Successive Deformylative P-C Cross-Couplings
复制标题
酶促去对称化和连续脱甲酰化 P-C 交叉偶联相结合合成 P-手性硫化膦
作者：
H. Ohta;Y. Nakashima;K. Kayahara;I. Tanaka;T. Tadokoro;Y. Watanabe;M. Hayashi
开发了一种通过酶促去对称制备的 P-手性前体进行顺序 Pd 催化立体特异性 P-C 偶联反应来合成 P-手性三芳基膦硫化物的方法。在温和条件下通过连续的 P-C 偶联可以将三个独立的芳基取代基引入到 P 原子上，同时保持高对映体纯度。
A process for the synthesis ofP-chiral triarylphosphine sulfides via sequential Pd-catalyzed stereospecific P–C coupling reactions ofP-chiral precursors prepared by enzymatic desymmetrization was developed. Three independent aryl substituents could be introduced onto the P atom by the sequential P–C couplings under mild conditions while retaining the high enantiopurity.