Interictal Slow and High-Frequency Oscillations: Is it an Epileptic Slow or Red Slow?
Interictal Slow and High-Frequency Oscillations: Is it an Epileptic Slow or Red Slow?
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DOI：
10.1097/wnp.0000000000000527
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发表时间：
2019-03-01
影响因子：
2.4
通讯作者：
Ikeda, Akio
中科院分区：
文献类型：
--
作者：
Inoue, Takeshi;Inouchi, Morito;Ikeda, Akio
目的：我们报告了发作间期的慢高频振荡（HFO）（IIS + HFO）的存在及其时间变化，以阐明其作为一个替代标记物的致痫区在一个顽固性局灶性epilepsy.Methods：我们专注于致痫性的核心电极之一，并调查IIS + HFO在前和后段的30分钟，所有6个癫痫发作。结果：6次癫痫发作前后，在致痫核心区的一个电极上，IIS + HFO共2,890个。发作后30 min内IIS + HFO数量显著减少。结论：200 ~ 399 μ V的IIS + HFO受癫痫发作的影响，癫痫发作后IIS + HFO的数量明显减少。它与发作时直流电漂移和发作时HFO一样，可反映致痫灶的核心部分。IIS + HFO可称为术语“红慢”，这可能有助于描绘至少一部分致痫区。
Purpose: We reported the presence of interictal slow and high-frequency oscillations (HFOs) (IIS + HFO) and its temporal change so as to elucidate its clinical usefulness as a surrogate marker of epileptogenic zone in a patient with intractable focal epilepsy.Methods: We focused on one of the core electrodes of epileptogenicity, and investigated IIS + HFO in the pre-and post-segment of 30 minutes to all the 6 seizures. We adopted interictal slow in duration of 0.33 to 10 seconds, amplitude >= 50 mV and co-occurring with HFOs, and then divided into 5 groups depending on the amplitude of slow wave.Results: Before and after all the 6 seizures, the number of IIS + HFO was 2,890 at one electrode in the core epileptogenic zone. The number of IIS + HFO significantly decreased for 30 minutes after seizures. Furthermore, the number of IIS + HFO with the amplitude of 200 to 399 mu V significantly decreased after seizures.Conclusions: IIS + HFO with the amplitude of 200 to 399 mu V was influenced by and decreased after seizures. It may reflect the core part of epileptogenic area as similarly as ictal direct current shifts and ictal HFOs do. IIS + HFO could be called as the term "red slow," which may be useful to delineate at least a part of the epileptogenic zone.