Role and activation of type III secretion system genes in Pseudomonas aeruginosa-induced Drosophila killing
Role and activation of type III secretion system genes in Pseudomonas aeruginosa-induced Drosophila killing
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DOI：
10.1006/mpat.2002.0504
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发表时间：
2002-06-01
影响因子：
3.8
通讯作者：
Attree, I
中科院分区：
文献类型：
--
作者：
Fauvarque, MO;Bergeret, E;Attree, I
铜绿假单胞菌PAO1和CHA在体外对巨噬细胞具有III型系统依赖的细胞毒作用，能够诱导果蝇迅速死亡，并伴随细菌的高滴度增殖。本文利用几个选择性影响铜绿假单胞菌III型分泌系统的等基因CHA突变体，证明了该分泌系统在快速灭蝇中的作用。铜绿假单胞菌PexsCBA的激活和果蝇基因敌百虫素的激活，表明了感染过程中宿主-病原菌的识别。(C)2002爱思唯尔科学有限公司。保留所有权利。
Pseudomonas aeruginosa strains PAO1 and CHA showing type III system-dependent cytotoxicity towards macrophages ex vivo are able to induce rapid death of adult fly Drosophila melanogaster accompanied by bacterial multiplication to high-titers. The role of P. aeruginosa type III secretion system in rapid fly killing was demonstrated here by using several isogenic CHA mutants, selectively affected in this system. The activation of P. aeruginosa pexsCBA, the regulatory operon of the type III system, and the activation of the Drosophila gene diptericin, showed the host-pathogen recognition during infection process. (C) 2002 Elsevier Science Ltd. All rights reserved.