Neural networks related to pro-saccades and anti-saccades revealed by independent component analysis
Neural networks related to pro-saccades and anti-saccades revealed by independent component analysis
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DOI：
10.1016/j.neuroimage.2012.06.006
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发表时间：
2012-09-01
期刊：
影响因子：
5.7
通讯作者：
Marek, Tadeusz
中科院分区：
文献类型：
--
作者：
Domagalik, Aleksandra;Beldzik, Ewa;Marek, Tadeusz
扫视眼动系统提供了一个很好的模型，研究基本的认知过程和灵活的控制行为。虽然亲扫视（PS）的机制是众所周知的，在反扫视任务（AS）的情况下，仍然不清楚哪些大脑区域在抑制对目标的反射性扫视中起作用，也不清楚矢量反转（即，在相反方向上定向）的确切机制。独立成分分析（伊卡）是用于建立时间相干脑区的方法之一，即与任务相关的神经网络。在本研究中，伊卡应用于功能磁共振成像数据从PS和AS实验。该研究揭示了负责向所需方向扫视生成的独立网络，自动反应的抑制以及矢量反转。第一个功能是由眼域网络完成的。自动反应的抑制与执行控制网络有关。向量反转似乎是由包括顶内沟、楔前叶/后扣带皮层、压后和海马旁在内的大量区域组成的网络完成的。这些区域与颞顶内侧通路有关，到目前为止只与导航有关。这些结果为理解抑制和矢量反转的过程提供了新的视角。(C)2012 Elsevier Inc. All rights reserved.
The saccadic eye movement system provides an excellent model for investigating basic cognitive processes and flexible control over behaviour. While the mechanism of pro-saccades (PS) is well known, in the case of the anti-saccade task (AS) it is still not clear which brain regions play a role in the inhibition of reflexive saccade to the target, nor what is the exact mechanism of vector inversion (i.e. orienting in the opposite direction). Independent component analysis (ICA) is one of the methods being used to establish temporally coherent brain regions, i.e. neural networks related to the task. In the present study ICA was applied to fMRI data from PS and AS experiments. The study revealed separate networks responsible for saccade generation into the desired direction, the inhibition of automatic responses, as well as vector inversion. The first function is accomplished by the eye fields network The inhibition of automatic responses is associated with the executive control network Vector inversion seems to be accomplished by the network comprising a large set of areas, including intraparietal sulcus, precuneus/posterior cingulate cortices, retrosplenial and parahippocampal. Those regions are associated with the parieto-medial temporal pathway, so far linked only to navigation. These results provide a new insight into understanding of the processes of the inhibition and vector inversion. (C) 2012 Elsevier Inc. All rights reserved.