Tetrahydrofolate biosynthesis and distribution in higher plants.
Tetrahydrofolate biosynthesis and distribution in higher plants.
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DOI：
10.1042/bst0330758
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发表时间：
2005-08
影响因子：
3.9
通讯作者：
T. Sahr;S. Ravanel;F. Rébeillé
中科院分区：
文献类型：
--
作者：
T. Sahr;S. Ravanel;F. Rébeillé
一碳转移反应由H4F（四氢叶酸）介导，H4F是一种可溶性辅酶（维生素B9），由植物和微生物从头合成，并由动物从饮食中吸收。H4F在植物中的合成是四分之一之间的质体，胞质溶胶和线粒体，空间分布，这是没有观察到在其他生物体，这表明一个复杂的细胞内交通。此外，H4F合成的活性在植物生长期间波动，这取决于幼苗的组织和发育阶段，从而说明了这些生物体中一碳代谢的灵活性。本文将着重介绍我们最近对植物细胞中H4F合成的认识，并简要描述该途径在幼苗生长发育过程中的活性。
One-carbon transfer reactions are mediated by H4F (tetrahydrofolate), a soluble coenzyme (vitamin B9) that is synthesized de novo by plants and microorganisms, and absorbed from the diet by animals. H4F synthesis in plants is quartered between the plastids, the cytosol and the mitochondria, a spatial distribution that is not observed in the other organisms and that suggests a complex intracellular traffic. Also, the activity of H4F synthesis fluctuates during plant growth, depending on the tissue and the developmental stage of the seedling, thus illustrating the flexibility of one-carbon metabolism in these organisms. This paper will focus on our recent knowledge about H4F synthesis in the plant cell and will briefly describe the activity of the pathway during the growth and development of the seedling.