Causes of Death in the Era of Highly Active Antiretroviral Therapy: A Retrospective Analysis of a Hybrid Hematology-Oncology and HIV Practice and the Seattle/King County Adult/Adolescent Spectrum of HIV-Related Diseases Project
Causes of Death in the Era of Highly Active Antiretroviral Therapy: A Retrospective Analysis of a Hybrid Hematology-Oncology and HIV Practice and the Seattle/King County Adult/Adolescent Spectrum of HIV-Related Diseases Project
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高效抗逆转录病毒治疗时代的死亡原因：混合血液学-肿瘤学和艾滋病毒实践以及西雅图/金县成人/青少年艾滋病毒相关疾病谱项目的回顾性分析
DOI：
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发表时间：
2008
影响因子：
3.1
通讯作者：
D. Aboulafia
中科院分区：
文献类型：
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作者：
Matthew C. Uhlenkott;S. Buskin;E. Kahle;Elizabeth A. Barash;D. Aboulafia
背景：在高效抗逆转录病毒治疗（HAART）时代，HIV感染者继续死亡。目的：通过回顾性比较分析，描述两个队列HAART时代的死亡原因。方法：弗吉尼亚梅森医学中心（VMMC）队列由600例死亡的HIV感染者组成。第二个队列包括来自成人和青少年疾病谱项目（Seattle-ASD）4721例患者的西雅图部分的351例死亡患者。提取的数据包括死亡时存在的疾病，定义为两个队列死亡时存在的任何主要发病原因。结果：非艾滋病定义疾病（非ADI）是VMMC和Seattle-ASD队列中分别有60%和45%的死亡率的主要来源。两个队列中最常见的致死性非ADI为癌症（7%和19%）、细菌感染（15%）和肝功能衰竭（9%和14%）。癌症（10%）和消瘦（7%）是两个队列中的主要致死性ADI。在每个队列中，患者死亡，尽管检测不到HIV病毒载量和CD 4+淋巴细胞计数>200个细胞/L。这包括60例VMMC患者中的11例（18%）（均死于非ADI）和351例Seattle-ASD患者中的35例（10%）（81%死于非ADI）。结论：在2个特征明确的城市HIV队列中，非ADI是HAART时代死亡的主要原因。尽管检测不到HIV病毒载量，并且通过CD 4+细胞计数测量的免疫功能保持良好，但这些患者中有相当数量的人死亡。
Background:HIV-infected patients continue to die in the era of highly active antiretroviral therapy (HAART). Objective:To describe the cause of mortality in the HAART era between 2 cohorts by conducting a comparative retrospective analysis. Methods:The Virginia Mason Medical Center (VMMC) cohort was composed of 60 died HIV-infected patients from 600 patients. The second cohort was comprised of 351 died patients from the Seattle portion of the Adult and Adolescent Spectrum of Diseases Project (Seattle-ASD) of 4721 patients. Among the abstracted data were the conditions present at death, defined as any major cause of morbidity present at death for both cohorts. Results:Non-AIDS defining illnesses (non-ADI) were a major source of mortality in 60% and 45% for the VMMC and Seattle-ASD cohorts, respectively. The most common fatal non-ADI in both cohorts were cancer (7% and 19%), bacterial infections (15%), and liver failure (9% and 14%). Cancer (10%) and wasting (7%) were prominent fatal ADI in both cohorts. In each cohort, patients died despite a nondetectable HIV viral load and a CD4+ lymphocyte count >200 cells/&mgr;L. This included 11 of 60 (18%) VMMC patients (all of whom died of non-ADI) and 35 of 351 (10%) Seattle-ASD patients (81% died with non-ADI). Conclusions:In 2 well-characterized urban HIV cohorts, non-ADI were a major cause of mortality in the HAART era. A substantial number of these patients died despite nondetectable HIV viral loads and reasonably well-preserved immune function measured by CD4+ cell counts.
影响因子：
11.8
作者：
Kushel, M. B.;Colfax, G.;Bangsberg, D. R.
通讯作者：
Bangsberg, D. R.
影响因子：
6.4
作者：
Walensky, Rochelle P.;Paltiel, A. David;Freedberg, Kenneth A.
通讯作者：
Freedberg, Kenneth A.