ChemBank:: a small-molecule screening and cheminformatics resource database
ChemBank:: a small-molecule screening and cheminformatics resource database
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DOI：
10.1093/nar/gkm843
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发表时间：
2008-01-01
影响因子：
14.9
通讯作者：
Clemons, Paul A.
中科院分区：
文献类型：
--
作者：
Seiler, Kathleen Petri;George, Gregory A.;Clemons, Paul A.
ChemBank (http://chembank.broad.harvard.edu/) 是一个公共的、基于网络的信息学环境，由哈佛大学和麻省理工学院博德研究所的化学生物学项目和平台合作开发。该知识环境包括源自小分子和小分子筛选的免费数据以及用于研究这些数据的资源。 ChemBank 在小分子数据库中是独一无二的，因为它致力于存储原始筛选数据，在统计假设检验方面对筛选实验进行严格定义，以及基于元数据将筛选实验组织成涉及相关分析集合的项目。 ChemBank 存储了一组日益多样化的测量数据，这些测量数据源自经过小分子处理的细胞和其他生物测定系统。分析工具已经可用并且正在不断开发，可以研究小分子、细胞测量和细胞状态之间的关系。目前，ChemBank 存储了数十万种小分子和数百种生物医学相关测定的信息，这些测定是由来自全球研究界的合作者在布罗德研究所进行的。 ChemBank 的目标是为生命科学家提供不受限制的访问迄今为止主要在私营部门提供的生物医学相关数据和工具。
ChemBank (http://chembank.broad.harvard.edu/) is a public, web-based informatics environment developed through a collaboration between the Chemical Biology Program and Platform at the Broad Institute of Harvard and MIT. This knowledge environment includes freely available data derived from small molecules and small-molecule screens and resources for studying these data. ChemBank is unique among small-molecule databases in its dedication to the storage of raw screening data, its rigorous definition of screening experiments in terms of statistical hypothesis testing, and its metadata-based organization of screening experiments into projects involving collections of related assays. ChemBank stores an increasingly varied set of measurements derived from cells and other biological assay systems treated with small molecules. Analysis tools are available and are continuously being developed that allow the relationships between small molecules, cell measurements, and cell states to be studied. Currently, ChemBank stores information on hundreds of thousands of small molecules and hundreds of biomedically relevant assays that have been performed at the Broad Institute by collaborators from the worldwide research community. The goal of ChemBank is to provide life scientists unfettered access to biomedically relevant data and tools heretofore available primarily in the private sector.