Natural course of knee osteoarthritis in middle-aged subjects with knee pain: 12-year follow-up using clinical and radiographic criteria
Natural course of knee osteoarthritis in middle-aged subjects with knee pain: 12-year follow-up using clinical and radiographic criteria
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DOI：
10.1136/ard.2008.095158
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发表时间：
2009-12-01
影响因子：
27.4
通讯作者：
Petersson, I. F.
中科院分区：
文献类型：
--
作者：
Thorstensson, C. A.;Andersson, M. L. E.;Petersson, I. F.
目的：探讨膝关节骨性关节炎（OA）的自然过程中，在中年人口与慢性knee pain.Methods：一个基于人口的样本143名受试者（平均年龄45（范围35-54），44%的女性）与膝关节疼痛（>3个月）在纳入研究。在基线和12年后获得负重胫股（TF）后前位X线片，并根据Kellgren/Lawrence（K/L）进行分类。在5年和12年随访时，使用skyline视图和= 1的截止点确定髌股（PF）OA：44/49（90%）例临床OA受试者和21/27（78%）例无临床OA受试者。65/67例（97%）TF OA患者在基线时出现进展。在5年的检查，26（31%）开发PF OA超过7 years.Conclusion：大多数慢性膝关节疼痛的受试者开发膝关节OA超过12年的84没有PF OA。结论：膝关节疼痛通常是膝关节OA的第一个体征。
Objective: To explore the natural course of knee osteoarthritis (OA) in a middle-aged population with chronic knee pain.Methods: A population-based sample of 143 subjects (mean age 45 (range 35-54), 44% women) with knee pain (>3 months) at inclusion was studied. Weightbearing posteroanterior tibiofemoral (TF) radiographs were obtained at baseline and 12 years later, and classified according to Kellgren/Lawrence (K/L). Patellofemoral (PF) OA was determined at 5-and 12-years' follow-up using a skyline view and a cut-off point of = 1): 44/49 (90%) of the subjects with clinical OA and 21/27 (78%) without clinical OA. Progression was found in 65/67 (97%) with TF OA at baseline. Of the 84 with no PF OA at the 5-year examination, 26 (31%) developed PF OA over 7 years.Conclusion: A majority of the subjects with chronic knee pain developed knee OA over 12 years. It is concluded that knee pain is often the first sign of knee OA.