INHIBITORS OF LYSOSOMAL-ENZYMES - ACCUMULATION OF LIPOFUSCIN-LIKE DENSE BODIES IN THE BRAIN
INHIBITORS OF LYSOSOMAL-ENZYMES - ACCUMULATION OF LIPOFUSCIN-LIKE DENSE BODIES IN THE BRAIN
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DOI：
10.1126/science.6505679
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发表时间：
1984-01-01
期刊：
影响因子：
56.9
通讯作者：
LYNCH, G
中科院分区：
文献类型：
--
作者：
IVY, GO;SCHOTTLER, F;LYNCH, G
将亮肽素（一种硫醇蛋白酶抑制剂）或氯喹（一种通用溶酶体酶抑制剂）注射到幼年大鼠的大脑中，诱导了溶酶体相关颗粒聚集体（致密体）的形成，该聚集体与在某些疾病状态和衰老过程中积累的蜡样脂褐质非常相似。致密物质以剂量和时间依赖性方式增加，并且在大脑区域和细胞类型中分布有差异。这些观察结果为蜡样脂褐素的起源提供了线索，并提出了研究其积累后果的方法。
Injections of leupeptin (a thiol proteinase inhibitor) or chloroquine (a general lysosomal enzyme inhibitor) into the brains of young rats induced the formation of lysosome-associated granular aggregates (dense bodies) which closely resembled the ceroid-lipofuscin that accumulates in certain disease states and during aging. The dense material increased in a dose- and time-dependent fashion and was differentially distributed across brain regions and cell types. These observations provide clues to the origins of ceroid-lipofuscin and suggest means for studying the consequences of its accumulation.