Genetic isolation of a blood pressure quantitative trait locus on chromosome 2 in the spontaneously hypertensive rat.
Genetic isolation of a blood pressure quantitative trait locus on chromosome 2 in the spontaneously hypertensive rat.
复制标题
自发性高血压大鼠 2 号染色体上血压数量性状位点的遗传分离。
DOI：
10.1097/00004872-200106000-00010
复制
发表时间：
2001
影响因子：
4.9
通讯作者：
Kurtz,TW
中科院分区：
文献类型：
--
作者：
Pravenec,M;Zídek,V;Musilová,A;Vorlícek,J;Kren,V;StLezin,E;Kurtz,TW
ObjectivesTotal genome scans of genetically segregating populations derived from the spontaneously hypertensive rat (SHR) and other rat models of hypertension have suggested the presence of quantitative trait loci (QTL) regulating blood pressure and cardiac mass on multiple chromosomes, including chromosome 2. The objective of the current study was to directly test for the presence of a blood pressure QTL on rat chromosome 2.DesignA new congenic strain was derived by replacing a segment of chromosome 2 in the SHR between D2Rat171 and D2Arb24 with the corresponding chromosome segment from the normotensive Brown Norway rat. Arterial pressures were directly monitored in conscious rats by radiotelemetry.ResultsWe found that the SHR congenic strain (SHR-2) carrying a segment of chromosome 2 from the Brown Norway rat had significantly lower systolic and diastolic blood pressures than the SHR progenitor strain. The attenuation of hypertension in the SHR-2 congenic strain versus the SHR progenitor strain was accompanied by significant amelioration of cardiac hypertrophy.ConclusionsThese findings demonstrate that gene (s) with major effects on blood pressure exist in the differential segment of chromosome 2 trapped within the new SHR. BN congenic strain.
